Mezlocillin sodium

Bezeichnung:Mezlocillin sodium

CAS-Nr59798-30-0

Englisch Name:Mezlocillin sodium

CBNumberCB4353793

SummenformelC22H27N6NaO9S2

Molgewicht606.6

MOL-Datei59798-30-0.mol

Mezlocillin sodium physikalisch-chemischer Eigenschaften

Schmelzpunkt	197-201°C (dec.)
storage temp.	Refrigerator
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in water or DMSO
CAS Datenbank	59798-30-0(CAS DataBase Reference)

Gefahreninformationscode (GHS)

Mezlocillin sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Mezlocillin is a β-lactam antibiotic and derivative of ampicillin . It is active against B. fragilis, E. lentum, P. morbillorum, and F. nucleatum (MICs = 8, 4, 2, and 4 μg/ml, respectively). Mezlocillin (32 μg/ml) is also active against 10 strains of S. faecalis. In vivo, mezlocillin (240 mg/kg) increases survival and reduces bacteremia in a rabbit model of S. faecalis endocarditis. It completely eliminates lung P. morbillorum, E. lentum, and F. nucelatum, but not B. fragilis, in a rabbit model of pulmonary P. morbillorum, E. lentum, F. nucelatum, and B. fragilis infection when administered at a dose of 300 mg/kg. Formulations containing mezlocillin have been used in the treatment of various bacterial infections.
Chemische Eigenschaften
Mezlocillin sodium is white to slightly yellow cryst. powder
Verwenden
Antibacterial.
Verwenden
Mezlocillin Sodium (cas# 59798-30-0) is a derivative of penicillin and an antimicrobial.
Definition
ChEBI: Mezlocillin sodium is an organic sodium salt. It contains a mezlocillin(1-).
Trademarks
Mezlin (Bayer).
Clinical Use
Mezlocillin (Mezlin) is an acylureidopenicillin with an antibacterialspectrum similar to that of carbenicillin andticarcillin; however, there are some major differences. It ismuch more active against most Klebsiella spp., P. aeruginosa,anaerobic bacteria (e.g., Streptococcus faecalis andB. fragilis), and H. influenzae. It is recommended for thetreatment of serious infections caused by these organisms.
Mezlocillin is not generally effective against β-lactamase–producing bacteria, nor is it active orally. It isavailable as a white, crystalline, water-soluble sodium saltfor injection. Solutions should be prepared freshly and, ifnot used within 24 hours, refrigerated. Mezlocillin and otheracylureidopenicillins, unlike carbenicillin, exhibit nonlinearpharmacokinetics. Peak plasma levels, half-life, and areaunder the time curve increase with increased dosage.Mezlocillin has less effect on bleeding time than carbenicillin,and it is less likely to cause hypokalemia.

Mezlocillin sodium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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