N,N'-Methantetraylbis(1-methylethylamin)

Bezeichnung:N,N'-Methantetraylbis(1-methylethylamin)

CAS-Nr693-13-0

Englisch Name:N,N'-Diisopropylcarbodiimide

CBNumberCB4301572

SummenformelC7H14N2

Molgewicht126.2

MOL-Datei693-13-0.mol

Synonyma

N,N'-Methantetraylbis(1-methylethylamin)

N,N'-Methantetraylbis(1-methylethylamin) physikalisch-chemischer Eigenschaften

Schmelzpunkt	210-2120C (dec)
Siedepunkt	145-148 °C(lit.)
Dichte	0.815 g/mL at 20 °C(lit.)
Dampfdruck	34.9hPa at 55.46℃
Brechungsindex	n20/D 1.433(lit.)
Flammpunkt	93 °F
storage temp.	Store below +30°C.
Löslichkeit	Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran.
Aggregatzustand	Liquid
Farbe	Clear colorless to yellow
Sensitive	Moisture Sensitive
BRN	878281
Stabilität	Volatile
InChIKey	BDNKZNFMNDZQMI-UHFFFAOYSA-N
LogP	4.11 at 20℃
CAS Datenbank	693-13-0(CAS DataBase Reference)
NIST chemische Informationen	2-Propanamine, N,N'-methanetetraylbis-(693-13-0)
EPA chemische Informationen	2-Propanamine, N,N'-methanetetraylbis- (693-13-0)

Sicherheit

Kennzeichnung gefährlicher	T+,T,F,Xn
R-Sätze:	10-26-36/37/38-41-42/43-37/38
S-Sätze:	26-36/37/39-45-38-28A-16-22
RIDADR	UN 2929 6.1/PG 1
WGK Germany	3
RTECS-Nr.	FF2175000
F	10-21
Hazard Note	Flammable/Highly Toxic/
TSCA	Yes
HazardClass	6.1
PackingGroup	II
HS Code	29252000
Giftige Stoffe Daten	693-13-0(Hazardous Substances Data)

Gefahreninformationscode (GHS)

N,N'-Diisopropylcarbodiimide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R10:Entzündlich.
R26:Sehr giftig beim Einatmen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R41:Gefahr ernster Augenschäden.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S38:Bei unzureichender Belüftung Atemschutzgerät anlegen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
Diisopropylcarbodiimide (DIC) is a clear liquid that can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker.
Chemische Eigenschaften
N,N'-Diisopropylcarbodiimide is colorless to pale yellow liquid. Insoluble in water, soluble in benzene, ethanol, ether.
Verwenden
N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. It is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature.
Definition
ChEBI: A carbodiimide compound having an isopropyl substituent on both nitrogen atoms.
Allgemeine Beschreibung
N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.
Kontakt-Allergie
It is used in peptide chemistry as a coupling reagent. It is very toxic and causes contact dermatitis in labora- tory workers.
Synthese
Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.

N,N'-Diisopropylcarbodiimide Upstream-Materialien And Downstream Produkte

N,N'-Methantetraylbis(1-methylethylamin) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

693-13-0, N,N'-Diisopropylcarbodiimide Verwandte Suche:

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