Metacetamol

Bezeichnung:Metacetamol

CAS-Nr621-42-1

Englisch Name:3-ACETAMIDOPHENOL

CBNumberCB0108898

SummenformelC8H9NO2

Molgewicht151.16

MOL-Datei621-42-1.mol

Synonyma

Metacetamol

Metacetamol physikalisch-chemischer Eigenschaften

Schmelzpunkt	145-148 °C(lit.)
Siedepunkt	273.17°C (rough estimate)
Dichte	1.249
Brechungsindex	1.5810 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol
pka	9.50±0.10(Predicted)
Aggregatzustand	Crystals, Crystalline Powder or Needles
Farbe	Off-white to tan or light gray
PH	6-7 (H2O)(saturated solution)
BRN	907998
CAS Datenbank	621-42-1(CAS DataBase Reference)
EPA chemische Informationen	3'-Hydroxyacetanilide (621-42-1)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38
S-Sätze:	26-36
RIDADR	2811
WGK Germany	2
RTECS-Nr.	AE4100000
F	1-8
Hazard Note	Irritant
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	29242995
Toxizität	LD50 intraperitoneal in mouse: 1025mg/kg

Gefahreninformationscode (GHS)

3-ACETAMIDOPHENOL Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
off-white to tan or light grey crystals,
Verwenden
3-Acetamidophenol is the ortho-regioisomer of Acetaminophen (A161220), an over-the-counter analgesic and antipyretic agent (1,2).
Definition
ChEBI: A derivative of phenol which has an acetamido substituent located meta to the phenolic -OH group. It is a non-toxic regioisomer of paracetamol with analgesic properties, but has never been marketed as a drug.
Allgemeine Beschreibung
Light gray solid.
Air & Water Reaktionen
Water insoluble.
Reaktivität anzeigen
Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Brandgefahr
Flash point data for 3-ACETAMIDOPHENOL are not available. 3-ACETAMIDOPHENOL is probably combustible.
läuterung methode
Recrystallise the phenol from water. The 3,5-dinitrobenzamide complex gives orange-yellow crystals from hot H2O and has m 212o. [Beilstein 13 H 415, 13 I 132, 13 II 213, 13 III 950, 13 IV 977.]

3-ACETAMIDOPHENOL Upstream-Materialien And Downstream Produkte

Metacetamol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

621-42-1, 3-ACETAMIDOPHENOL Verwandte Suche:

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