4-Chlor-2-methylchinolin

Bezeichnung:4-Chlor-2-methylchinolin

CAS-Nr4295-06-1

Englisch Name:4-CHLORO-2-METHYLQUINOLINE

CBNumberCB4286158

SummenformelC10H8ClN

Molgewicht177.63

MOL-Datei4295-06-1.mol

Synonyma

4-Chlor-2-methylchinolin

4-Chlor-2-methylchinolin physikalisch-chemischer Eigenschaften

Schmelzpunkt	39 °C
Siedepunkt	269-270 °C (lit.)
Dichte	0.881 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.622(lit.)
Flammpunkt	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	4.40±0.50(Predicted)
Aggregatzustand	powder to lump to clear liquid
Farbe	White or Colorless to Yellow
Wasserlöslichkeit	Slightly soluble in water.
BRN	3522
InChI	InChI=1S/C10H8ClN/c1-7-6-9(11)8-4-2-3-5-10(8)12-7/h2-6H,1H3
InChIKey	HQAIROMRVBVWSK-UHFFFAOYSA-N
SMILES	N1C2C(=CC=CC=2)C(Cl)=CC=1C
CAS Datenbank	4295-06-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39
WGK Germany	3
HS Code	2933499090
Speicherklasse	10 - Combustible liquids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

4-CHLORO-2-METHYLQUINOLINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Melting point 42-43℃, boiling point 269-270℃, 83℃ (93Pa), relative density 0.881, refractive index 1.6224. Slightly soluble in water.
Verwenden
4-Chloroquinaldine is used in the preparation of 4-phenyl-hydrazinoquinaldine
Synthese

607-67-0

4295-06-1

General procedure: 4-hydroxy-2-methylquinoline (5a-c) was added to POCl3 and the reaction mixture was heated to reflux for 12 hours. Upon completion of the reaction, the excess POCl3 was removed by distillation under reduced pressure. the residue was washed once and twice each with CHCl3 and toluene sequentially. The solid obtained was dissolved in CH2Cl2 and triethylamine was added dropwise until the pH of the aqueous wash solution was greater than 10. Finally, the reaction mixture was filtered to afford the target products 2-methyl-4-chloroquinoline (6a-c).
Einzelnachweise
[1] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 1114 - 1125
[2] Patent: US2008/171765, 2008, A1. Location in patent: Page/Page column 19-20
[3] Australian Journal of Chemistry, 2003, vol. 56, # 1, p. 39 - 44
[4] Letters in Drug Design and Discovery, 2018, vol. 15, # 9, p. 937 - 944
[5] Patent: WO2018/178277, 2018, A1. Location in patent: Paragraph 00114

4-CHLORO-2-METHYLQUINOLINE Upstream-Materialien And Downstream Produkte

4-Chlor-2-methylchinolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4295-06-1, 4-CHLORO-2-METHYLQUINOLINE Verwandte Suche:

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