Artemether

Bezeichnung:Artemether

CAS-Nr71963-77-4

Englisch Name:Artemether

CBNumberCB4248286

SummenformelC16H26O5

Molgewicht298.37

MOL-Datei71963-77-4.mol

Artemether physikalisch-chemischer Eigenschaften

Schmelzpunkt	86-88°C
alpha	D19.5 +171° (c = 2.59 in CHCl3)
Siedepunkt	359.79°C (rough estimate)
Dichte	1.0733 (rough estimate)
Brechungsindex	1.6200 (estimate)
storage temp.	room temp
Löslichkeit	DMSO: ≥20mg/mL
Aggregatzustand	powder
Farbe	off-white to light brown
Optische Aktivität	[α]/D +155 to +175°, c = 0.5 in methanol
Merck	14,815
InChI	InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
InChIKey	SXYIRMFQILZOAM-HVNFFKDJSA-N
SMILES	O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](OC)O4)O1

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	KD4165000
HS Code	29329930
Giftige Stoffe Daten	71963-77-4(Hazardous Substances Data)
Toxizität	LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu)

Gefahreninformationscode (GHS)

Artemether Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC₅₀s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD₅₀) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.
Chemische Eigenschaften
White Solid
Verwenden
Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.
Verwenden
atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist
Verwenden
Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when
Definition
ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria.
Allgemeine Beschreibung
Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant.
Biochem/physiol Actions
Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.
Sicherheitsprofil
Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.
target
Antifection
Lager
Store at -20°C

Artemether Upstream-Materialien And Downstream Produkte

Artemether Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

71963-77-4, Artemether Verwandte Suche:

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