Amlodipine Besylate Produkt Beschreibung

Amlodipine Besylate Struktur
111470-99-6
  • CAS-Nr.111470-99-6
  • Bezeichnung:Amlodipine Besylate
  • Englisch Name:Amlodipine Besylate
  • Synonyma:
    Amlor;Vazkor;Amcard;Lowrac;Norvas;NORVASC;Amdepin;Amdipin;Amlodin;Amlopin
  • CBNumber:CB4127875
  • Summenformel:C26H31ClN2O8S
  • Molgewicht:567.05094
  • MOL-Datei:111470-99-6.mol
Amlodipine Besylate physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :199-201°C
  • storage temp.  :2-8°C
  • Löslichkeit :DMSO: 20 mg/mL
  • Aggregatzustand :solid
  • pka :8.6
  • Farbe :white
  • Wasserlöslichkeit :Soluble in DMSO (20 mg/mL), water (10 mM), chloroform, ethanol (14 mg/mL), and methanol.
  • Merck  :14,491
  • InChIKey :ZPBWCRDSRKPIDG-UHFFFAOYSA-N
  • CAS Datenbank :111470-99-6(CAS DataBase Reference)
Sicherheit
  • Kennzeichnung gefährlicher :Xn
  • R-Sätze: :22-36/37/38-20/21/22
  • S-Sätze: :26-36
  • WGK Germany  :3
  • RTECS-Nr. :US7967700
  • HS Code  :29333990

Amlodipine Besylate Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Beschreibung Anilodipine besylate is a new, once-daily, dihydropyridine calcium antagonist useful in the treatment of hypertension and angina.
  • Chemische Eigenschaften White Crystalline Solid
  • Originator Pfizer (USA)
  • Verwenden A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive
  • Verwenden Angiotensin II inhibitor prodrug, antihypertensive
  • Verwenden Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.
  • Definition ChEBI: The benzenesulfonate salt of amlodipine.
  • Manufacturing Process 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5- methoxycarbonyl-6-methyl-1,4-dihydropyridine (amlodipine) was prepared from 2-(phthalimidoaminoethoxy)acetoacetate, 2-chlorobenzaldehyde and methyl-3-aminocrotonate under refluxing in ethanol for 24 hours. The ketoester was prepared by the method of Troostwijk and Kellog (JCS Chem. Comm., 1977, p.932). Methyl-3-aminocrotonate can be prepared by known method. Phthalimido-amino-protecting group was removed using hydrazine hydrate in ethanol at the reflux temperature.
    Although amlodipine is effective as the free base, in practice it is best administered form of a salt of a pharmaceutically acceptable acid.
    Benzensulphonic salt of amlodipine was prepared as follows: Amlodipine base (65.6 g, 0.161 mols) was slurried in industrial methylated spirit (denatured alcohol, 326.4 ml) and cooled to 5°C. Benzensulphonic acid (26.2 g, 0.168 mols) was dissolved in industrial methylated spirit (65.6 ml) at 5°C and added to base. The resulting slurry was then granulated, filtered and washed with 2 volumes the same solvent (65.6 ml). The damp solid was slurred at 5°C for 1 hr in 327.6 ml industrial methylated spirit, filtered, washed with 2 volumes of the same solvent (65.6 ml) and dried under vacuum at 55°C for 24 hr. A yield of besylate salt of amlodipine 65 g.
  • Trademarks Norvasc (Pfizer);Istin.
  • Therapeutic Function Antianginal, Antihypertensive
  • Biologische Aktivität L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).
  • Veterinary Drugs and Treatments Oral amlodipine appears to be a useful agent in the treatment of hypertension in cats and many consider it the drug of choice for this indication. In pharmacokinetic studies, amlodipine has decreased blood pressure in dogs with chronic renal disease, but its efficacy in treating hypertensive dogs has been disappointing.
    Hypertension in cats is usually secondary to other diseases (often renal failure or cardiac causes such as thyrotoxic cardiomyopathy or primary hypertrophic cardiomyopathy, etc.) and is most often seen in middle-aged or geriatric cats. These animals often present with acute clinical signs such as blindness, seizures, collapse or paresis. A cat is generally considered hypertensive if systolic blood pressure is >160 mmHg. Early reports indicate that if antihypertensive therapy is begun acutely, some vision may be restored in about 50% of cases of blindness secondary to hypertension.
Amlodipine Besylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Amlodipine Besylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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111470-99-6, Amlodipine Besylate Verwandte Suche:
  • Vazkor
  • 3-Ethyl 5-Methyl 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Benzenesulfonate 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfona
  • 3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate
  • AMlodipine bes
  • Amlodipine besilate (crystalline)
  • 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate
  • raw material amlodipine besylate
  • Amlodipine Beaylate
  • 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid-3-ethyl 5-methyl ester, benzenesulfonate (1:1)
  • Amlodipine besylate Amlodipine besilate
  • 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfonate
  • 3-Ethyl 5-Methyl 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydro
  • 2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE
  • 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate
  • Amlodipine Besylate (350 mg)
  • Amlodipine benzene sulfonic acid amlodipine
  • Ethyl 2-[(2-aminoethoxy)methyl]-4-(2-chloropohenyl)-1,4-dihydro-5-(methoxycarbonyl)-6-methylpyridine-3-carboxylate benzenesulphonate
  • 2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl=5-methyl·benzenesulfonic acid
  • C20H25ClN2O5C6H5SO3H
  • Amlodipine besilate 111470-99-6
  • AMLODIPINE BENZENESULFONATE
  • AMLODIPINE BESILATE
  • AMLODIPINE BESYLATE
  • NORVASC
  • 3,5-pyridinedicarboxylicacid,2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,
  • 4-dihydro-6-methyl-,3-ethyl-5-methylester,monobenzenesulfonate
  • AMLODIPINE BESILATE MM(CRM STANDARD)
  • AMLODIPINE BESYLATE EPY(CRM STANDARD)
  • AMLODIPINEBESYLATE(SUBJECTTOPATENTFREE)
  • (+-)-3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate monobenzenesulfonate
  • 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, monobenzenesulfonate
  • Amcard
  • Amdepin
  • Amdipin
  • Amlodin
  • Amlopin
  • Amlor
  • Amlosyn
  • Antacal
  • Benzenesulfonic acid, compd. with 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate (1:1)
  • Calchek
  • Lowrac
  • Monopina
  • Norvas
  • Norvask
  • Tensivask
  • UK 48340-26
  • 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-ethyl ester O5-methyl ester
  • Amlodipine Besilate RS
  • Amlodipine Besylate &gt
  • Amlodipine besilate CRS
  • Amlodipine for peak identification CRS
  • Amlodipine Besylte
  • Amlodipine besilate Solution,100μg/mL
  • 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfona
  • Amlodipine Besylate USP/EP/BP
  • AmlodipineBesilatehcl88150-42-9 USP/EP/BP
  • 111470-99-6