Guanoxan

Bezeichnung:Guanoxan

CAS-Nr2165-19-7

Englisch Name:Guanoxan

CBNumberCB41117509

SummenformelC10H13N3O2

Molgewicht207.23

MOL-Datei2165-19-7.mol

Guanoxan physikalisch-chemischer Eigenschaften

Schmelzpunkt	164-165°
Siedepunkt	339.3±45.0 °C(Predicted)
Dichte	1.40±0.1 g/cm3(Predicted)
pka	pKa 12.3 (Uncertain)

Guanoxan Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Envacar,Pfizer
Verwenden
Guanoxan is a sympatholytic drug related to Guanethidine (G815000). Guanoxan is used in the treatment of hypertension.
Definition
ChEBI: Guanoxan is a benzodioxine.
Manufacturing Process
2 Methods of producing of 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine:
1. 3.3 parts by weight of 2-aminomethyl-1,4-benzodioxane and 2.78 parts by weight of S-methylisothiouronium sulfate were dissolved in 20 parts by volume of water, and the resulting aqueous solution was heated under reflux for 3 h. At the end of this time, the solvent was removed by means of evaporation under reduced pressure and the residue so obtained dissolved in a minimum amount of fresh water and treated with charcoal. Upon filtration, there was obtained a clear filtrate which, on standing, soon afforded pure crystals of di(2-guanidinomethyl-1,4-benzodioxane)sulfate, melting point 204°-205°C.
The base 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine may be obtained by reaction of di(2-guanidinomethyl-1,4-benzodioxane)sulfate with, for example, sodium hydroxide.
2. o-Dihydroxybenzene reacted with epichlorhydrine in the presence sodium hydroxide and 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine was obtained. To solution of 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine thionylchloride was added to give 2-chlormethyl-2,3-dihydro-1,4-benzodioxine.
2-Chloromethyl-2,3-dihydro-1,4-benzodioxine reacted with benzylamine to produced 2-benzylaminomethyl-2,3-dihydro-1,4-benzodioxine, which was reduced at the presence of hydrogen and Pd-C (catalyst) to 2-aminomethyl- 2,3-dihydro-1,4-benzodioxine.
2-Aminomethyl-2,3-dihydro-1,4-benzodioxine was treated by Smethylisothiouronium sulfate and there was produced 2-guanidinemethyl-2,3- dihydro-1,4-benzodioxine.
Trademarks
Envacar (Pfizer).
Therapeutic Function
Antihypertensive

Guanoxan Upstream-Materialien And Downstream Produkte

Guanoxan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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