BAPTA Struktur

BAPTA

Bezeichnung:BAPTA

CAS-Nr85233-19-8

Englisch Name:BAPTA

CBNumberCB3406887

SummenformelC22H24N2O10

Molgewicht476.43

MOL-Datei85233-19-8.mol

BAPTA physikalisch-chemischer Eigenschaften

Schmelzpunkt	177-179 °C
Siedepunkt	575.89°C (rough estimate)
Dichte	1.4482 (rough estimate)
Brechungsindex	1.6500 (estimate)
RTECS-Nr.	MC0423000
storage temp.	2-8°C
Löslichkeit	Soluble in dimethyl sulfoxide
Aggregatzustand	Powder
pka	1.40±0.10(Predicted)
Farbe	White to off-white
Wasserlöslichkeit	Soluble in water and sodium bicarbonate.
maximale Wellenlänge (λmax)	209 nm, 254 nm, 203 nm, 274 nm
Merck	14,957
BRN	5192406
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Biologische Anwendungen	Calcium indicators; zinc indicators; treating acute cell death,cerebral infarction,myocardial infarction,hepatonecrosis,kidney ischemic necrosis,necrotizing pancreatitis,amyloidosis,atherosclerosis,diseases characteriz
InChIKey	FTEDXVNDVHYDQW-UHFFFAOYSA-N
CAS Datenbank	85233-19-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
HS Code	29225090

Gefahreninformationscode (GHS)

BAPTA Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
BAPTA free acid (85233-19-8) is a selective extracellular Ca2+ chelator. It is a widely used calcium sponge for chelating Ca2+?outside of intact cells.1 It’s a useful tool to probe the involvement of extracellular Ca2+ in cellular signaling.2,3 Non-cell-permeable.
Chemische Eigenschaften
White Solid
Verwenden
Highly selective calcium chelating reagent. Suitable for the spectrophotometric monitoring of Ca2+ levels.
Verwenden
As calcium chelator; 19F labelled forms for measurement of intracellular calcium.
Verwenden
BAPTA is a highly selective calcium chelating reagent. Lipophilic diesters of the chelating agent 1,2-Bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) are used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE.
Definition
ChEBI: A polyamino carboxylic acid in which bis(carboxymethyl)nitrilo groups are bonded to C-2 and C-2' of 1,1'-[ethane-1,2-diylbis(oxy)]dibenzene.
Allgemeine Beschreibung
In nature 1,2-Bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetra acetic acid (BAPTA) is a main metabolic product of BAPTA -AM (BAPTA-tetra(actoxymethyl ester), a neuro protective agent in cerebral ischemia, in rats.BAPTA is an intercellular Ca²⁺ chelator.
Biologische Aktivität
Selective calcium chelator.
Lager
Store at +4°C
Einzelnachweise
1) Munoz et al. (2015), Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus; PLoS One, 10(9) e0138008 2) Wozniak et al. (2017), Extracellular Ca2+ is Required for Fertilization in the African Clawed Frog, Xenopus laevis; PLoS One, 12(1) e0170405 3) Didiasova et al. (2015), STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization; J. Biol. Chem., 290 11983

BAPTA Upstream-Materialien And Downstream Produkte

BAPTA Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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