N-Acetyl-L-methionin

Bezeichnung:N-Acetyl-L-methionin

CAS-Nr65-82-7

Englisch Name:N-Acetyl-L-methionine

CBNumberCB3394487

SummenformelC7H13NO3S

Molgewicht191.25

MOL-Datei65-82-7.mol

Synonyma

N-Acetyl-L-methionin

N-Acetyl-L-methionin physikalisch-chemischer Eigenschaften

Schmelzpunkt	103-106 °C(lit.)
alpha	-20 º (c=4 H2O)
Siedepunkt	235 °C(Press: 12 Torr)
Dichte	1.2684 (rough estimate)
Brechungsindex	-21 ° (C=1, H2O)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	methanol: soluble100mg/mL, clear, colorless
pka	3.50±0.10(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Optische Rotation	[α]20/D -21.0±1.0°, c = 1% in H2O
Merck	14,96
BRN	1725552
Stabilität	Stable. Incompatible with strong oxidizing agents.
Major Application	peptide synthesis
Kosmetik-Inhaltsstoffe Funktionen	SKIN CONDITIONING
Erinnerung an die inhaltsstoffe	N-Acetyl-L-methionine (65-82-7)
InChI	1S/C7H13NO3S/c1-5(9)8-6(7(10)11)3-4-12-2/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)/t6-/m0/s1
InChIKey	XUYPXLNMDZIRQH-LURJTMIESA-N
SMILES	CSCC[C@H](NC(C)=O)C(O)=O
LogP	-0.885 (est)
CAS Datenbank	65-82-7(CAS DataBase Reference)
NIST chemische Informationen	N-acetylmethionine(65-82-7)
EPA chemische Informationen	L-Methionine, N-acetyl- (65-82-7)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	24/25-36-26
WGK Germany	3
RTECS-Nr.	PD0480000
TSCA	TSCA listed
HazardClass	IRRITANT
HS Code	29309070
Speicherklasse	11 - Combustible Solids

Gefahreninformationscode (GHS)

N-Acetyl-L-methionine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white crystals
Verwenden
N-Acetyl-L-methionine (CAS# 65-82-7) has been useful in the study of metabolic phenotypes of standard and cold-stored platelets.
Definition
ChEBI: An L-methionine derivative that is L-methionine in which one of the amine hydrogens is substituted by an acetyl group.
reaction suitability
reaction type: solution phase peptide synthesis
Sicherheitsprofil
Poison by intravenous route. When heated to decomposition emits toxic fumes of NOX,.
Synthese

60-35-5

3268-49-3

65-82-7

Example 1: To a stainless steel reactor equipped with a thermocouple, a stirrer, a gas supply line and a liquid supply line, 5.40 g (0.016 mol) of octacarbonyldicobalt(0) [Co2(CO)8] and 39.86 g of 1,4-dioxane (38.7 wt% of the total 1,4-dioxane) were added and stirred. Subsequently, a mixture of carbon monoxide and hydrogen [CO/H2 = 2.3/1 (molar ratio)] was introduced into the reactor to bring the pressure in the reactor to 13 MPa (gauge pressure). The temperature of the reactor was increased to 68-72 °C while maintaining stirring, at which time the pressure in the reactor was maintained at 13 MPa (gauge pressure). Next, 31.57 g (0.30 mol) of 3-(methylthio)propionaldehyde [compound shown in formula (2), wherein R1 is 2-methylthioethyl], 18.08 g (0.30 mol) of acetamide [compound shown in formula (3), wherein R2 is a methyl group and R3 is a hydrogen atom], 63.14 g of 1 ,4-dioxane (as a proportion of the total amount of 1,4-dioxane 61.3 wt%) and 5.40 g of water in a mixed solution with a titration time of 1.5 hours. After the dropwise addition, the reaction was continued with stirring at 68-72 °C for 4 h. Subsequent cooling to 5-35 °C gave 158.3 g of 1,4-dioxane solution containing N-acetyl-L-methionine. The yield of N-acetyl-L-methionine in this solution was analyzed by liquid chromatography to be 85.5% relative to 3-(methylthio)propionaldehyde.
läuterung methode
Crystallise N-acetyl-L-methionine from Me2CO, H2O or EtOAc. Dry it in a vacuum over P2O5. Its solubility at 25o in H2O is 30.7%, and in Me2CO it is 29.5%. [Mitzi & Schueter Biochim Biophys Acta 27 168 1958, Birnbaum et al. J Biol Chem 194 455 1952, Beilstein 4 IV 3206.]
Einzelnachweise
[1] Patent: US2013/116469, 2013, A1. Location in patent: Paragraph 0030

N-Acetyl-L-methionine Upstream-Materialien And Downstream Produkte

N-Acetyl-L-methionin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

65-82-7, N-Acetyl-L-methionine Verwandte Suche:

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