Clopidogrel Produkt Beschreibung

Clopidogrel Struktur
113665-84-2
  • CAS-Nr.113665-84-2
  • Bezeichnung:Clopidogrel
  • Englisch Name:Clopidogrel
  • Synonyma:
    CLOPIDOGREL;Chlopidogrel;ClopidogrelHcl;Clopidogrel–d4;(S)-Clopidogrel;Clopidogrel-13C3;Clopidogrel Pellets;Clopidogrel Free base;Clopidogrel USP/EP/BP;ClopidogrelHydrobromide
  • CBNumber:CB3341209
  • Summenformel:C16 H16 Cl N O2 S
  • Molgewicht:321.82
  • MOL-Datei:113665-84-2.mol
Clopidogrel physikalisch-chemischer Eigenschaften
  • alpha  :D20 +51.52° (c = 1.61 in methanol)
  • Siedepunkt: :423.7±45.0 °C(Predicted)
  • Dichte :1.317±0.06 g/cm3(Predicted)
  • storage temp.  :Sealed in dry,2-8°C
  • pka :4.56±0.20(Predicted)
  • CAS Datenbank :113665-84-2(CAS DataBase Reference)
Sicherheit

Clopidogrel Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Beschreibung Clopidogrel was launched in the US as a potent inhibitor of platelet aggregation for the preventive management of secondary ischemic events, including MI, stroke and vascular deaths. Clopidogrel can be synthesized in 4 steps (including an optical resolution to the S active enantiomer) from 2-(2- ch1orophenyl)-glycine, the key step being the cyclization to thienopyridine with formaldehyde and acetic acid. Clopidogrel belongs to the original chemical class of Ticlopidine, but shows fewer side effects (in particular, bone-marrowsuppressing effects) at the dosage generally used. Like Ticlopidine, it is an Adenosine diphosphate (ADP) antagonist acting at the purinergic P2y receptor. In in vivo experiments with rabbits, Clopidogrel shows a maximal antiaggregant effect at 20mg/kg po, reducing adhesion of platelets to the vascular subendothelium ; moreover, it reduces myointimal thickening occuring after endothelial injury of rat carotid artery. Clopigrel does not affect platelet aggregation in vitro ; actually, its in vivo activity is highly dependent on hepatic metabolism. The results of a CAPRIE trial (Clopidogrel versus Aspirin in patients at risk of ischemic events) demonstrated that Clopidogrel was well tolerated and more effective than aspirin.
  • Originator Sanofi (France)
  • Verwenden anthelmintic, antiparasitic, antimite
  • Verwenden Sertraline metabolite
  • Trademarks Plavix (Sanofi Aventis);Plavix, Iscover.
  • Allgemeine Beschreibung Clopidogrel, methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate sulfate (Plavix), is useful for the preventativemanagement of secondary ischemic events, including myocardialinfarction, stroke, and vascular deaths. It may beclassified as a thienopyridine because of its heterocyclicsystem. Several agents possessing this system have beenevaluated as potential antithrombotic agents. These agentshave a unique mechanism, in that they inhibit the purinergicreceptor located on platelets. Normally, nucleotides act asagonists on these receptors, which include the P2Y type.Two P2Y receptor subtypes (P2Y1 and P2Y2) found onplatelets, when stimulated by adenosine diphosphate (ADP),cause platelet aggregation.
  • Clinical Use Clopidogrel acts as an antagonistto the P2Y2 receptor. It is probably a prodrug that requiresmetabolic activation, because in vitro studies do not interferewith platelet aggregation. Although platelet aggregationis not normally seen in the first 8 to 11 days after administrationto a patient, the effect lasts for several days after thedrug therapy is discontinued. Unlike other thienopyridinescurrently used, clopidogrel does not seriously reduce thenumber of white cells in the blood, and therefore, routinemonitoring of the white blood cell count is not necessaryduring treatment.
Clopidogrel Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Clopidogrel Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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113665-84-2, Clopidogrel Verwandte Suche:
  • CLOPIDOGREL
  • methyl (2s)-2-(2-chlorophenyl)-2-(9-thia-4-azabicyclo[4.3.0]nona-7,10-dien-4-yl)acetate
  • ClopidogrelHydrobromide
  • ClopidogrelHydrogenSulfateBase
  • ClopidogrelHcl
  • Methyl (+)-(S)-α-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate
  • (S)- α-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acidmethyl ester
  • Clopidogrel Pellets
  • Methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate
  • Clopidogrel-13C3
  • Clopidogrel-d4 (RaceMic)
  • D-(+)-Methyl-alpha-(4,5,6,7-tetrahydro-thieno[3,2-c]Pyridyl)(2chlorophenyl)acetate
  • (S)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
  • Chlopidogrel
  • (S)-alpha-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate hydrogen sulfate
  • Clopidrogel Carboxylic Acid
  • Clopidogrel BaseMethyl-α-(2-Chlorophenyl)-6,7-Dihyd rothieno 3,2-c Pyridine-5(4H)-Acetate, Sulfate(1 1)
  • Clopidogrel hydrogen sulfide salts
  • Clopidogrel Free base
  • Clopidogrel EP impurity-C (USP RC C) Su
  • Clopidogrel EP Impurity C ( Su)
  • CLOPIDOGREL BISULPHATE FORM 1
  • (S)-Clopidogrel
  • Clopidogrel–d4
  • Methyl (2S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate
  • Clopidogrel for system suitability CRS
  • Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (αS)-
  • Clopidogrel USP/EP/BP
  • 113665-84-2
  • 65-84-2
  • C16H16ClNO2S
  • REVOLUTION
  • Pharmaceutical intermediates
  • API's
  • API
  • Cardiovascular