5-HYDROXYTRYPTOPHOL Struktur

5-Hydroxy-1H-indol-3-ethanol

Bezeichnung:5-Hydroxy-1H-indol-3-ethanol

CAS-Nr154-02-9

Englisch Name:5-HYDROXYTRYPTOPHOL

CBNumberCB3250862

SummenformelC10H11NO2

Molgewicht177.2

MOL-Datei154-02-9.mol

Synonyma

5-Hydroxy-1H-indol-3-ethanol

5-Hydroxy-1H-indol-3-ethanol physikalisch-chemischer Eigenschaften

Schmelzpunkt	111-113°
Siedepunkt	435.2±30.0 °C(Predicted)
Dichte	1.356±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
pka	10.07±0.40(Predicted)
Aggregatzustand	Solid
Farbe	White to Light Red

Sicherheit

RTECS-Nr.	NL8512500
HS Code	2933998090

Gefahreninformationscode (GHS)

5-HYDROXYTRYPTOPHOL Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Off-White Crystalline Powder
Verwenden
A metabolite of Tryptophan (T947200).
Definition
ChEBI: 5-Hydroxytryptophol is a member of indoles.
Hazard
A reproductive hazard.
Biologische Aktivität
5-hydroxy tryptophol is a metabolite of tryptophan.tryptophan (encoded by the codon ugg) is an α-amino acid that is used in the biosynthesis of proteins. tryptophan has an α-amino group, an α-carboxylic acid group, and a side chain indole, demonstrating it as a non-polar, aromatic amino acid. tryptophan is critical in humans, but the body cannot synthesize it and therefore tryptophan must be obtained from the diet. tryptophan is also found to be a precursor to the neurotransmitters serotonin and melatonin.
in vitro
in previous studies, 5-hydroxy tryptophol was identified as a metabolite of tryptophan that was formed by the alcohol dehydrogenase-catalyzed reduction of the serotonin intermediate, 5-hydroxyindoleacetaldehyde. moreover, depending on the tissue nad/nadh ratio, the acetaldehyde intermediate could also be oxidized by aldehyde dehydrogenase to form 5-hydroxyindoleacetic acid. therefore, the ratio of 5-hydroxy tryptophol to 5-hydroxyindoleacetic acid could be used as a biomarker for recent alcohol consumption [1,2].
Einzelnachweise
[1] yokoyama, m. t. and carlson, j.r. dissimilation of tryptophan and related indolic compounds by ruminal microorganisms in vitro. appl.microbiol. 27(3), 540-548 (1974).
[2] beck, o. ,stephanson, n.,btthcer, m., et al. biomarkers to disclose recent intake of alcohol: potential of 5-hydroxytryptophol glucuronide testing using new direct uplc-tandem ms and elisa methods. alcohol & alcoholism 42(4), 321-325 (2007).

5-HYDROXYTRYPTOPHOL Upstream-Materialien And Downstream Produkte

5-Hydroxy-1H-indol-3-ethanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

154-02-9, 5-HYDROXYTRYPTOPHOL Verwandte Suche:

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