Ethyl-2-amino-6-[(4-fluorbenzyl)amino]pyridin-3-carbamat, Verbindung mit Maleinsure (1:1)

Bezeichnung:Ethyl-2-amino-6-[(4-fluorbenzyl)amino]pyridin-3-carbamat, Verbindung mit Maleinsure (1:1)

CAS-Nr75507-68-5

Englisch Name:Flupirtine maleate

CBNumberCB2805021

SummenformelC19H21FN4O6

Molgewicht420.3916432

MOL-Datei75507-68-5.mol

Synonyma

Ethyl-2-amino-6-[(4-fluorbenzyl)amino]pyridin-3-carbamat, Verbindung mit Maleinsure (1:1)

Ethyl-2-amino-6-[(4-fluorbenzyl)amino]pyridin-3-carbamat, Verbindung mit Maleinsure (1:1) physikalisch-chemischer Eigenschaften

Schmelzpunkt	186-188°C
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	DMSO: soluble >20mg/mL
Aggregatzustand	solid
Farbe	white
maximale Wellenlänge (λmax)	343nm(CH3CN)(lit.)
Merck	14,4190
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey	DPYIXBFZUMCMJM-BTJKTKAUSA-N

Sicherheit

S-Sätze:	22-24/25-35-20
WGK Germany	3
RTECS-Nr.	EY8555800
HS Code	29333990

Gefahreninformationscode (GHS)

Flupirtine maleate Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Flupirtine maleate is a centrally-acting, non-addicting analgesic agent somewhat more potent than aspirin, paracetamol and pentazocine. It is reported to be useful in the treatment of postoperative and dental pain.
Beschreibung
Flupirtine is an activator of voltage-gated potassium channel 7 (K_v7/KCNQ). It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT⁺) mice. Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular hypertrophy in hypoxia-induced and SERT⁺ mouse models of pulmonary arterial hypertension. It increases the paw withdrawal threshold in a rat model of streptozotocin-induced diabetic neuropathy when administered at a dose of 10 mg/kg and increases paw withdrawal latency in a rat model of carrageenan-induced paw inflammation when used in combination with morphine. Flupirtine also indirectly antagonizes NMDA receptors via its effects on potassium channels.
Chemische Eigenschaften
Off-White Solid
Originator
Chemiewerk Homburg (Degussa) (W. Germany)
Verwenden
Analgesic. Substituted pyridine with central analgesic properties. A potassium channel opener.
Verwenden
Analgesic. Substituted pyridine with central analgesic properties.
Trademarks
KATADOLAN
Biologische Aktivität
Non-opioid analgesic with muscle relaxant properties. Activates K + channels and indirectly antagonizes NMDA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.
Lager
Desiccate at +4°C
Einzelnachweise
1) Azad?et al. (2004), The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice; Neuro. Sci. Lett.,?370?186 2) Klinger?et al.?(2012),?Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine; Br. J. Pharmacol.,?166?1631 3) Osbourne?et al. (1998),?Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist; Gen. Pharmacol.,?30?255

Flupirtine maleate Upstream-Materialien And Downstream Produkte

Ethyl-2-amino-6-[(4-fluorbenzyl)amino]pyridin-3-carbamat, Verbindung mit Maleinsure (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

75507-68-5, Flupirtine maleate Verwandte Suche:

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