4-Fluorphenylhydrazinhydrochlorid

Bezeichnung:4-Fluorphenylhydrazinhydrochlorid

CAS-Nr823-85-8

Englisch Name:4-Fluorophenylhydrazine hydrochloride

CBNumberCB2746728

SummenformelC6H8ClFN2

Molgewicht162.59

MOL-Datei823-85-8.mol

Synonyma

4-Fluorphenylhydrazinhydrochlorid

4-Fluorphenylhydrazinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	≥300 °C(lit.)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Aggregatzustand	Powder
Farbe	White to brownish
Wasserlöslichkeit	soluble
BRN	3627721
InChI	InChI=1S/C6H7FN2.ClH/c7-5-1-3-6(9-8)4-2-5;/h1-4,9H,8H2;1H
InChIKey	FEKUXLUOKFSMRO-UHFFFAOYSA-N
SMILES	N(C1=CC=C(F)C=C1)N.[H]Cl
CAS Datenbank	823-85-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-43-40-20/21/22
S-Sätze:	26-36-36/37/39-22
RIDADR	2811
WGK Germany	3
HazardClass	IRRITANT
HS Code	29280090
Speicherklasse	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 Carc. 1B Skin Sens. 1

Gefahreninformationscode (GHS)

4-Fluorophenylhydrazine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R43:Sensibilisierung durch Hautkontakt möglich.
R40:Verdacht auf krebserzeugende Wirkung.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
light red powde
Verwenden
4-Fluorophenylhydrazine hydrochloride is used as a chemical intermediate in the pharmaceutica1ls particularly of tryptamine drugs used in the treatment of migraine and cluster headaches. It is used to prepare agrochemical, and other chemical. It is used to detect sugars and aldehydes in analytical chemistry.
Synthese

371-40-4

823-85-8

The general procedure for the synthesis of 4-fluorophenylhydrazine hydrochloride from 4-fluoroaniline was as follows: 4-fluoroaniline (127.6 g, 1 mol) was dissolved in concentrated hydrochloric acid (293 mL) and stirred for 2 hours at room temperature. Subsequently, the above solution was slowly added dropwise to a solution of sodium nitrite (72.5 g, 1.05 mol) in water (145 mL) at a temperature controlled below 5 °C. After the dropwise addition, stirring was continued for 1 hour, and then the filtrate was separated by filtration to obtain the filtrate. A solution of NaHSO3 (213.2 g, 2.05 mol) in water (500 mL) was slowly added dropwise to the filtrate over a temperature range of 0-10 °C while the pH was adjusted with 25% NaOH solution to maintain between 6-7. The reaction mixture was heated to 80 °C and maintained at this temperature for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and then concentrated hydrochloric acid (600 mL) was added dropwise. Next, the mixture was heated to 90-100°C for 1 hour. Finally, the mixture was cooled to 10 °C and the precipitate was collected by filtration to give the light red solid product 4-fluorophenylhydrazine hydrochloride (129.3 g, 60% yield).
Einzelnachweise
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 3149 - 3157
[2] Archiv der Pharmazie (Weinheim, Germany), 1994, vol. 327, # 2, p. 99 - 104
[3] Die Pharmazie, 1985, vol. 40, # 1, p. 21 - 22
[4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[5] Angewandte Chemie - International Edition, 2010, vol. 49, # 50, p. 9769 - 9772

4-Fluorophenylhydrazine hydrochloride Upstream-Materialien And Downstream Produkte

4-Fluorphenylhydrazinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

823-85-8, 4-Fluorophenylhydrazine hydrochloride Verwandte Suche:

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