4-Fluoranilin

Bezeichnung:4-Fluoranilin

CAS-Nr371-40-4

Englisch Name:4-Fluoroaniline

CBNumberCB8143013

SummenformelC6H6FN

Molgewicht111.12

MOL-Datei371-40-4.mol

Synonyma

4-Fluoranilin

4-Fluoranilin physikalisch-chemischer Eigenschaften

Schmelzpunkt	-1.9 °C
Siedepunkt	187 °C/767 mmHg (lit.)
Dichte	1.173 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.539(lit.)
Flammpunkt	165 °F
storage temp.	2-8°C
Löslichkeit	33g/l
pka	4.65(at 25℃)
Aggregatzustand	Oily Liquid
Wichte	1.173
Farbe	Clear pale yellow to red-brown
Wasserlöslichkeit	33 g/L (20 ºC)
Merck	14,4169
BRN	742030
Stabilität	Stable. Incompatible with acids, oxidizing agents.
CAS Datenbank	371-40-4(CAS DataBase Reference)
NIST chemische Informationen	p-Fluoroaniline(371-40-4)
EPA chemische Informationen	p-Fluoroaniline (371-40-4)

Sicherheit

Kennzeichnung gefährlicher	C,T,Xi,Xn
R-Sätze:	22-34-36/38-33-23/24/25
S-Sätze:	26-36/37/39-45-37/39-28
RIDADR	UN 2941 6.1/PG 3
WGK Germany	1
RTECS-Nr.	BY1575000
Hazard Note	Toxic/Irritant
TSCA	T
HazardClass	6.1
PackingGroup	III
HS Code	29214210
Giftige Stoffe Daten	371-40-4(Hazardous Substances Data)

Gefahreninformationscode (GHS)

4-Fluoroaniline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R34:Verursacht Verätzungen.
R36/38:Reizt die Augen und die Haut.
R33:Gefahr kumulativer Wirkungen.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
Chemische Eigenschaften
4-Fluoroaniline is a light yellow to gold-coloured liquid.It is easy to oxidize and turn red in air.
Verwenden
4-Fluoroaniline is a degradation product of Ezetimibe (E975000). 4-Fluoroaniline is used as an analytical reagent in the enzymic detection of glucose.
Verwenden
4-Fluoroaniline may be employed as one of the target pollutant during the investigation of biodegradability of fluorinated compounds under aerobic conditions. It may be used for the synthesis of luminescent and cationic monocyclometalated gold(III) monoaryl complexes.
Verwenden
Intermediate in the manufacture of herbicides and plant growth regulators.
synthetische
The better process in the one-step process is the nitrobenzene method, which is obtained by deoxygenation, hydrogenation and fluorination. With PdCl2-V2O5 as the catalyst and carbon monoxide as the reducing agent, the reaction was carried out at 160°C for 3h, and the yield of 4-fluoroaniline could reach 90%, with another 10% of aniline as a by-product. With PtO2 as the catalyst, BF3-HF as the fluorinating agent and hydrogen as the reducing agent, the reaction was carried out at 42℃ for 12.5h, with 100% conversion and 95% yield.
Definition
ChEBI: 4-fluoroaniline is a primary arylamine that is the derivative of aniline in which the hydrogen at position 4 has been substituted by fluorine. It is used as an intermediate in the manufacture of pharmaceuticals, herbicides and plant growth regulators. It is a primary arylamine and a fluoroaniline.
Synthesis Reference(s)
Journal of the American Chemical Society, 70, p. 654, 1948 DOI: 10.1021/ja01182a065
The Journal of Organic Chemistry, 26, p. 4014, 1961 DOI: 10.1021/jo01068a089
Allgemeine Beschreibung
4-fluoroaniline is a light-colored oily liquid. Mixture of three isomers. Insoluble in water and denser than water. Contact may cause irritation to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals. The barriers to inversion and internal rotation of the NH2 group in 4-fluoroaniline has been investigated by far infrared gas spectra.
Hazard
Toxic material.
Flammability and Explosibility
Not classified
Sicherheitsprofil
Poison by ingestion. Mutation data reported. A severe skin and eye irritant. When heated to decomposition it emits very toxic fumes of NOx and F-.

4-Fluoroaniline Upstream-Materialien And Downstream Produkte

4-Fluoranilin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

371-40-4, 4-Fluoroaniline Verwandte Suche:

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