2-P-ANISYL-1,3-INDANDIONE Struktur

2-P-ANISYL-1,3-INDANDIONE

Bezeichnung:2-P-ANISYL-1,3-INDANDIONE

CAS-Nr117-37-3

Englisch Name:2-P-ANISYL-1,3-INDANDIONE

CBNumberCB2689681

SummenformelC16H12O3

Molgewicht252.26

MOL-Datei117-37-3.mol

2-P-ANISYL-1,3-INDANDIONE physikalisch-chemischer Eigenschaften

Schmelzpunkt	156-157°
Siedepunkt	355.44°C (rough estimate)
Dichte	1.1824 (rough estimate)
Brechungsindex	1.5600 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Slightly)
Aggregatzustand	Solid
pka	pKa 4.13(H2O t=25.0±0.1 I=0.1(NaCl)) (Uncertain)
Farbe	White to Off-White
EPA chemische Informationen	Anisindione (117-37-3)

Sicherheit

RIDADR	2811
HazardClass	6.1(b)
PackingGroup	III
Giftige Stoffe Daten	117-37-3(Hazardous Substances Data)
Toxizität	mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),Journal of Medicinal Chemistry. Vol. 28, Pg. 1591, 1985.

Gefahreninformationscode (GHS)

2-P-ANISYL-1,3-INDANDIONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Slightly beige or yellow powder
Originator
Miradon,Schering,US,1960
Verwenden
radiopaque agent
Verwenden
Anisindione is a synthetic anticoagulant that prevents the formation of active procoagulation factors and proteins in the liver.
Definition
ChEBI: A cyclic beta-diketone consisting of indane-1,3-dione having a 4-methoxyphenyl substituent at the 4-position.
Manufacturing Process
To a hot solution of 20.6 g of sodium in 400 ml of absolute ethanol, there is added a solution of 110 g of phthalide and 110 g of p-methoxybenzaldehyde. A vigorous reaction ensues and one-half of the alcohol is distilled off over a two hour period. Ice and water are added to the red solution and the diluted solution is acidified with hydrochloric acid. The resulting gum solidifies and the aqueous phase is removed by decantation. The crude solid is recrystallized twice from two liters of ethanol yielding 2-(p-methoxyphenyl)-1,3-indandione as pale yellow crystals, MP 155-156°C.
Trademarks
Miradon (Schering).
Therapeutic Function
Anticoagulant
Allgemeine Beschreibung
Anisindione, 2-(p-methoxyphenyl)-1,3-indandione, 2-(p-anisyl)-1,3-indandione (Miradon), is ap-methoxy congener of phenindione. It is a white, crystallinepowder, slightly soluble in water, tasteless, and absorbedwell after oral administration.
In instances when the urine may be alkaline, an orangecolor may be detected. This is caused by metabolic productsof anisindione and is not hematuria.
läuterung methode
Crystallise anisidinone from acetic acid or EtOH. [Horeau & Jacqius Bull Soc Chim Fr 53 1948, Koelsch J Am Chem. Soc 58 1331 1936, Beilstein 8 III 2931.]

2-P-ANISYL-1,3-INDANDIONE Upstream-Materialien And Downstream Produkte

2-P-ANISYL-1,3-INDANDIONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

117-37-3, 2-P-ANISYL-1,3-INDANDIONE Verwandte Suche:

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