5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion

Bezeichnung:5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion

CAS-Nr532-11-6

Englisch Name:Anethole trithione

CBNumberCB0168937

SummenformelC10H8OS3

Molgewicht240.36

MOL-Datei532-11-6.mol

Synonyma

5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion

5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion physikalisch-chemischer Eigenschaften

Schmelzpunkt	111°
Siedepunkt	353.09°C (rough estimate)
Dichte	1.4406 (rough estimate)
Brechungsindex	1.5080 (estimate)
storage temp.	2-8°C
Löslichkeit	Chloroform[soluble in]
Löslichkeit	soluble in Chloroform
Aggregatzustand	powder to crystal
Farbe	Orange-colored prisms from butyl acetate
Geruch (Odor)	very bitter taste
InChI	InChI=1S/C10H8OS3/c1-11-8-4-2-7(3-5-8)9-6-10(12)14-13-9/h2-6H,1H3
InChIKey	KYLIZBIRMBGUOP-UHFFFAOYSA-N
SMILES	S1C(C2=CC=C(OC)C=C2)=CC(=S)S1
CAS Datenbank	532-11-6(CAS DataBase Reference)
NIST chemische Informationen	3H-1,2-Dithiole-3-thione, 5-(4-methoxyphenyl)-(532-11-6)

Sicherheit

HS Code	2934.99.3000
Toxizität	LD50 orl-mus: 3850 mg/kg NIIRDN 6,25,82

Gefahreninformationscode (GHS)

Anethole trithione Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Sialor,Paladin Labs
Verwenden
Anethole trithione is a choleretic drug that can be effective in the treatment of dry mouth, including drug-induced xerostomia. Research suggests that Anethole trithione may exert its therapeutic effects by acting on the alpha-CGRP nerves in the salivary glands, which in turn promotes salivary secretion^[1-2].
Definition
ChEBI: Anetholtrithion is a member of methoxybenzenes.
Manufacturing Process
1 mol anethol (1-methoxy-4-propenyl-benzene) and 3 mol sulfur were heated in an open vessel to temperature 190°-200°C. H2S was removed at this temperature. On cooling the reaction mixture was getting solid. The solid product was recrystallizated from acetone or ethanol to give the orange-red needles of 5-(4-methoxyphenyl)-3H-1,2-dithiole-3-thione; MP 108.5°C.
Therapeutic Function
Salivation stimulant, Choleretic, Neuroprotective
Sicherheitsprofil
Poison by intramuscular route.Moderately toxic by ingestion and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of SOx.
Einzelnachweise
[1] TOSHIAKI NAGANO; Masaharu T. Enhancement of salivary secretion and neuropeptide (substance P, α-calcitonin gene-related peptide) levels in saliva by chronic anethole trithione treatment[J]. Journal of Pharmacy and Pharmacology, 2010. DOI:10.1211/0022357011778098.
[2] GLENERT U. Effects of chronic anethole trithione and amitriptyline treatment on rat parotid gland signalling[J]. European Journal of Pharmacology: Molecular Pharmacology, 1992. DOI:10.1016/0922-4106(92)90081-6.

Anethole trithione Upstream-Materialien And Downstream Produkte

5-(4-Methoxyphenyl)-3H-1,2-dithiol-3-thion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

532-11-6, Anethole trithione Verwandte Suche:

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