Galantaminhydrobromid

Bezeichnung:Galantaminhydrobromid

CAS-Nr1953-04-4

Englisch Name:Galantamine Hydrobromide

CBNumberCB2439815

SummenformelC17H22BrNO3

Molgewicht368.27

MOL-Datei1953-04-4.mol

Synonyma

Galantaminhydrobromid

Galantaminhydrobromid physikalisch-chemischer Eigenschaften

Schmelzpunkt	256 °C
alpha	D20 -93.1° (c = 0.1015 in 15 ml H2O)
Brechungsindex	-95 ° (C=1.4, H2O)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Sparingly soluble in water, very slightly soluble in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
Aggregatzustand	White to off-white crystalline solid.
Farbe	White to Orange to Green
Wasserlöslichkeit	Soluble in water or DMSO
Merck	14,4340
InChI	InChI=1/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/s3
InChIKey	QORVDGQLPPAFRS-ORFATOSYNA-N
SMILES	[C@@]123CCN(C)CC4=CC=C(OC)C(O[C@H]1C[C@@H](O)C=C2)=C34.Br \|&1:0,14,16,r\|
LogP	1.750 (est)
CAS Datenbank	1953-04-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	45-36/37/39-22
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	DF8075000
HazardClass	6.1
PackingGroup	II
HS Code	29399990
Toxizität	LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess)

Gefahreninformationscode (GHS)

Galantamine Hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
Galantamine hydrobromide is a white to almost white powder and is sparingly soluble in water.
Verwenden
Galantamine hydrobromide (marketed as Reminyl) is one of a group of three drugs for people with Alzheimer's disease called cholinesterase inhibitors. The other two are called donepezil hydrochloride (common brand name Aricept) and rivastigmine (common brand name Exelon). It is a selective acetylcholinesterase inhibitor that for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism.
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Galantamine Hydrobromide, a reversible, competitive acetyl cholinesterase inhibitor, is suggested for the remedy of mild to moderate dementia of the Alzheimer′s type.
Biologische Aktivität
Long-acting, centrally active acetylcholinesterase inhibitor (IC 50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β -amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.
target
AChR | AChE
Lager
Store at RT

Galantaminhydrobromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1953-04-4, Galantamine Hydrobromide Verwandte Suche:

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