FMOC-S-trityl-L-cysteine

Bezeichnung:FMOC-S-trityl-L-cysteine

CAS-Nr103213-32-7

Englisch Name:FMOC-S-trityl-L-cysteine

CBNumberCB2138770

SummenformelC37H31NO4S

Molgewicht585.71

MOL-Datei103213-32-7.mol

FMOC-S-trityl-L-cysteine physikalisch-chemischer Eigenschaften

Schmelzpunkt	170-173 °C(lit.)
Siedepunkt	763.4±60.0 °C(Predicted)
alpha	16 º (c=1, THF)
Dichte	1.270±0.06 g/cm3(Predicted)
Brechungsindex	18 ° (C=1, THF)
storage temp.	2-8°C
Löslichkeit	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	3.70±0.10(Predicted)
Aggregatzustand	Powder
Farbe	White to almost white
Optische Aktivität	[α]20/D +16.0±2°, c = 1% in THF
Wasserlöslichkeit	Insoluble in water. Soluble in most organic solvents.
BRN	4221286
InChIKey	KLBPUVPNPAJWHZ-UMSFTDKQSA-N
CAS Datenbank	103213-32-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	22-24/25-26
WGK Germany	3
F	9-21
Hazard Note	Irritant
HS Code	29309090

Gefahreninformationscode (GHS)

FMOC-S-trityl-L-cysteine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to light yellow crystal powde
Verwenden
Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative used in peptide synthesis. Some of the examples are:
- Synthesis of mono- and bi-functionalized platinum(IV) complexes to target angiogenic tumor vasculature.
- Synthesis of proteins through native chemical ligation of peptide hydrazides as thioester surrogates via solid-phase synthesis.
- Synthesis of glycoconjugates by conjugating reducing sugars to cysteine residues of peptides.
Verwenden
It is potentially useful for proteomics studies, and solid phase peptide synthesis techniques. Cysteine is versatile amino acid involved with many biological processes, including the formation of disulfide bonds - a critical component of protein structure. This compound could be useful as an unusual amino acid analog to aid in the deconvolution of protein structure and function.
Allgemeine Beschreibung
The standard derivative for Fmoc SPPS of peptides containing Cys [1]. The Trt group is removed with 95% TFA containing 1-5% TIS. Ideally, this derivative should be introduced using the symmetrical anhydride or DIPCDI/HOBt activation [2,3] to minimize enantiomerization. If activation with uronium or phosphonium reagents, such as HBTU or PyBOP^?, is to be employed, it is strongly recommended that collidine is used as the base [4], as this has been shown to significantly reduce loss of optical integrity during coupling.

The product number for this product was previously 04-12-1018.

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FMOC-S-trityl-L-cysteine Upstream-Materialien And Downstream Produkte

FMOC-S-trityl-L-cysteine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

103213-32-7, FMOC-S-trityl-L-cysteine Verwandte Suche:

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