6-bromo-1,2,3,4-tetrahydroisoquinoline

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P405：Unter Verschluss aufbewahren.

6-bromo-1,2,3,4-tetrahydroisoquinoline Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  34784-05-9

  

  226942-29-6

  NaBH4 (3.46 g, 91.51 mmol) was slowly added to a solution of acetic acid (90 mL) containing 6-bromoisoquinoline (4.76 g, 22.88 mmol) at room temperature with continuous stirring for 1.5 h. The reaction was carried out using a mixture of ethyl acetate and THF. Upon completion of the reaction, water was added to the mixture and the pH was adjusted to 8 with an aqueous solution of 8 N sodium hydroxide.Subsequently, the reaction mixture was extracted three times using a solvent mixture of ethyl acetate/THF (3:1, v/v). The organic layers were combined, washed with water and dried with magnesium sulfate. After removal of the solvent by evaporation under reduced pressure, the residue was purified by silica gel column chromatography (using NH silica gel, solvent gradient: 20%→90% ethyl acetate/hexanes) to afford the target compound, 6-bromo-1,2,3,4-tetrahydroisoquinoline (3.26 g, 15.37 mmol, 67.2% yield), as a colorless oil.1H NMR (300 MHz, CDCl3 ) data were as follows: δ 1.63 (1H, s), 2.77 (2H, t, J = 6.0 Hz), 3.11 (2H, t, J = 5.9 Hz), 3.95 (2H, s), 6.85-6.90 (1H, m), 7.21-7.26 (2H, m).

• Einzelnachweise

  [1] Patent: EP3192791, 2017, A1. Location in patent: Paragraph 0593
  [2] Patent: WO2013/80222, 2013, A1. Location in patent: Page/Page column 39
  [3] Applied Catalysis A: General, 2018, vol. 560, p. 37 - 41

6-bromo-1,2,3,4-tetrahydroisoquinoline Upstream-Materialien And Downstream Produkte

6-bromo-1,2,3,4-tetrahydroisoquinoline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(158)Suppliers

226942-29-6, 6-bromo-1,2,3,4-tetrahydroisoquinoline Verwandte Suche: