Hexetidin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P337+P313：Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Hexetidine Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R36/38:Reizt die Augen und die Haut.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Chemische Eigenschaften

  Liquid.Soluble in methanol, benzene, and petroleum ether; insoluble in water.

• Chemische Eigenschaften

  Hexetidine is a colorless or faint yellow-colored oily liquid with a characteristic amine odor.

• Originator

  Sterisil,Warner Lambert,US,1956

• Verwenden

  Hexetidine, mixture of stereoisomers is an antibacterial and antifungal agent. Used in plant-derived composite antimicrobial agent and application thereof in cosmetic.

• Verwenden

  Fungicide, bactericide, algicide, antistatic agent for synthetics, insect repellent, medicine (antifungal agent).

• Verwenden

  Involved in studies:
  
  • To identify pure liquid salt forms of aspirin
  • Of alkyl based selective displacers for protein purification via ion exchange chromatography
  • Of the in vivo application of models for testing drugs against nonreplicating Mycobacterium tuberculosis
  • Nutrient-sensitized screening for drugs that shift the energy metabolism from mitochondrial respiration to glycolysis
  • Inhibition of angiogensis
  • Screening antimalarial drugs

• Definition

  ChEBI: 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine is an organonitrogen heterocyclic compound and an organic heteromonocyclic compound.

• Vorbereitung Methode

  Hexetidine is prepared by hydrogenation under pressure of 1,3- bis(2-ethylhexyl)-5-methyl-4-nitrohexahydropyriminine at 100°C using Raney nickel as a catalyst.

• Manufacturing Process

  Nitroethane and formaldehyde are first reacted to give 2-methyl-2-nitro-1,3- propanediol. This is reacted with 2-ethylhexylamine and formaldehyde to give 5-nitro-1,3-bis(2-ethylhexyl)-5-methyl-hexahydropyrimidine.
  To a hydrogenation apparatus containing 500 ml of methanol and 10 g of Raney nickel catalyst were continuously added over a period of one hour, 240 g of 5-nitro-1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidine. During the one-hour period, the resulting mixture was hydrogenated at approximately 1,000 pounds per square inch utilizing room temperature as the initial temperature and gradually increasing the temperature to about 70°C. At the end of the one-hour period, hydrogenation was stopped. The reaction mixture was first filtered to remove the catalyst and was then distilled at atmospheric pressure at a temperature of 70°C to remove methanol. 197.5 g of 5-amino- 1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidine were collected.

• Therapeutic Function

  Antifungal

• Allgemeine Beschreibung

  The effectiveness of a hexetidine mouthwash in reducing supragingival plaque and gingival inflammation has been examined.

• Hazard

  Combustible.

• Pharmazeutische Anwendungen

  Hexetidine is used as an antimicrobial preservative in cosmetics and nonparenteral pharmaceutical formulations. Therapeutically, hexetidine is mainly used as a 0.1% w/v solution in mouthwash formulations for the prevention and treatment of minor local infections, gingivitis, and mouth ulcers.

• Sicherheit(Safety)

  Hexetidine is mainly used in mouthwashes as a bactericidal and fungicidal antiseptic. It is also used as an antimicrobial preservative and is generally regarded as a relatively nontoxic and nonirritant material at concentrations up to 0.1% w/v. Allergic contact dermatitis and altered olfactory and taste perception have occasionally been reported. Hexetidine is toxic when administered intravenously.
  Solutions of hexetidine in oil at concentrations of 5–10% w/v cause strong primary irritations without sensitization in humans. Long-term toxicological studies of up to 0.1% w/w of hexetidine in food for 1 year do not show any toxic effect. Fetotoxicity, embryotoxicity, and teratogenicity studies in rats of doses up to 50 mg/kg/day exhibit no sign of toxicity.
  LD100 (cat, IV): 5–20 mg/kg
  LD50 (dog, oral): 1.60 g/kg
  LD50 (mouse, IP): 0.142 g/kg
  LD50 (mouse, oral): 1.52 g/kg
  LD50 (rat, oral): 0.61–1.43 g/kg

• Lager

  Hexetidine is stable and should be stored in a well-closed container in a cool, dry place. Brass and copper equipment should not be used for the handling or storage of hexetidine.

• Inkompatibilitäten

  Hexetidine is incompatible with strong oxidizing agents. Salts are formed with mineral and organic acids; strong acids cause opening of the hexahydropyrimidine ring, releasing formaldehyde.

• Regulatory Status

  Included in nonparenteral formulations licensed in Europe.

Hexetidine Upstream-Materialien And Downstream Produkte

Hexetidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(161)Suppliers

141-94-6, Hexetidine Verwandte Suche: