Docetaxel Produkt Beschreibung

Docetaxel Struktur
114977-28-5
  • CAS-Nr.114977-28-5
  • Bezeichnung:Docetaxel
  • Englisch Name:Docetaxel
  • Synonyma:
    rp56976;TAXOTERE;Docetere;BIND-014;Decetaxel;Doxetaxel;Docetaxel;NSC_628503;Taxotere(R);DOCETAXEL(P)
  • CBNumber:CB1163212
  • Summenformel:C43H53NO14
  • Molgewicht:807.87922
  • MOL-Datei:114977-28-5.mol
Docetaxel physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :186-192 °C (dec.)
  • alpha  :-36 º (c=0.74,EtOH)
  • Dichte :1.38
  • storage temp.  :Store at +4°C
  • Löslichkeit :Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride.
  • Aggregatzustand :neat
  • Wasserlöslichkeit :Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.
  • Merck  :14,3397
  • InChIKey :BEDLLNJKXXVTSX-LWWLJZAUSA-N
  • CAS Datenbank :114977-28-5(CAS DataBase Reference)
Sicherheit

Docetaxel Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  • Beschreibung Docetaxel, a semi-synthetic product from the taxoid family, was launched in 1995 first in South Africa and subsequently in several other markets for the treatment of ovarian, breast and non-small cell lung cancers. Like the naturally occurring antitumor agent paclitaxel, the first marketed taxoid, docetaxel promotes both the rate and extent of tubulin assembly into stable microtubules and inhibits their depolymerization. It acts as a mitotic spindle poison and induces a mitotic block in proliferating cells. This mechanism of action for taxoids is unique from other classes of anticancer agents. Docetaxel was reported to be twice as potent as paclitaxel in several in vitro protocols and also exhibit higher cytotoxicity. Clinical trials are on going for docetaxel for other types of tumors including pancreatic, gastric, head and neck cancers and soft tissue sarcomas.
  • Chemische Eigenschaften Off-white Cryst
  • Originator Rhone-Poulenc Rorer (France)
  • Verwenden Docetaxel is a semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM). It has proven more effective than taxol in preventing the proliferation of cancer cells. Docetaxel has applications in breast cancer and hormone-refractory prostate cancer. This product is intended for research applications.
  • Verwenden antineoplastic;binds to microtubules
  • Definition ChEBI: A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.
  • Trademarks Taxotere (Sanofi Aventis).
  • Hazard A poison. Human systemic effects.
Docetaxel Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Docetaxel Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global(499)Suppliers
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114977-28-5, Docetaxel Verwandte Suche:
  • -,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydr
  • benzenepropanoicacid,beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy
  • beta-s*),11-alpha,12-alpha,12a-alpha,12b-alpha))-a-r
  • o-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4
  • rp56976
  • DOCETAXEL (TAXOTERE)
  • DocetaxelAnhydrous/Trihydrate
  • DocetaxelAnhydrousin-HouseStandard
  • Docetaxel99.5%
  • [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylesterbenzenepropanoicacid
  • Docetaxel >99%
  • Docetaxel£DOC
  • Decetaxel anhydrous
  • Docetaxel Anhydrous(Taxotere)
  • (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]aMino}-2-hydroxy-3-phenylpropanoyl]oxy}-1,9,12-trihydroxy-10,14,17,17-tetraMethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl benzoate
  • [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyc
  • Benzenepropanoic acid, beta-[[(1,1-diMethylethoxy)carbonyl]aMino]-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano
  • Anhydrous Docetaxel
  • Docetere
  • Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
  • Docetaxel N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol
  • Taxotere anhydrous
  • Decetaxel
  • TAXOTERE
  • n-debenzoyl-n-tert-butoxycarbonyl-10-deacetyl taxol
  • )benz(1,2-b)oxet-9-ylester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alph
  • Benzenepropanoic acid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trih ydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,bS)-
  • DOCETAXEL ANHYDROUS 99.5%
  • Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
  • docetaxcel,DTX
  • N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl
  • Docetaxel(other anti-cancers)
  • Docetaxel
  • DOCETAXEL OR TAXOTERE
  • N-DEBENZOYL-N-BOC-10-DEACETYL TAXOL
  • Taxotere(R)
  • NSC_628503
  • Benzenepropanoic acid, beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR,betaS)-
  • Docetaxel9.5%
  • Docetaxel (Trihydrate/Anhydrous)
  • DOCETAXEL(P)
  • BIND-014
  • Doxetaxel
  • 114977-28-5
  • 148408-66-5
  • C43H53NO14
  • C43H55NO13
  • Plant extracts
  • Herb extract
  • API
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • inhibitor
  • -
  • Inhibitors