1,4:3,6-Dianhydro-D-glucitol

Bezeichnung:1,4:3,6-Dianhydro-D-glucitol

CAS-Nr652-67-5

Englisch Name:Isosorbide

CBNumberCB1162705

SummenformelC6H10O4

Molgewicht146.14

MOL-Datei652-67-5.mol

Synonyma

1,4:3,6-Dianhydro-D-glucitol

1,4:3,6-Dianhydro-D-glucitol physikalisch-chemischer Eigenschaften

Schmelzpunkt	60-63 °C (lit.)
Siedepunkt	175°C/2mmHg(lit.)
alpha	42 º (c=3, H2O)
Dichte	1.0945 (rough estimate)
Dampfdruck	0.007Pa at 20℃
Brechungsindex	45 ° (C=5, H2O)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka	13.17±0.40(Predicted)
Aggregatzustand	Crystals, Crystalline Solid or Mass
Farbe	Off-white to light yellow or beige
Optische Aktivität	[α]20/D +45.2°, c = 3 in H2O
Wasserlöslichkeit	Soluble in alcohols, water and ketones.
Sensitive	Hygroscopic
Merck	14,5224
BRN	80510
InChIKey	KLDXJTOLSGUMSJ-JGWLITMVSA-N
LogP	-1.39 at 20℃
CAS Datenbank	652-67-5(CAS DataBase Reference)
EPA chemische Informationen	D-Glucitol, 1,4:3,6-dianhydro- (652-67-5)

Sicherheit

R-Sätze:	22
S-Sätze:	24/25
WGK Germany	2
RTECS-Nr.	LZ4380000
TSCA	Yes
HS Code	29349990
Giftige Stoffe Daten	652-67-5(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Isosorbide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
off-white to light yellow or beige crystals,
Verwenden
pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics.
Verwenden
D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters.
Verwenden
Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.
Definition
A polyol with a hydroxyl group attached to each of two cis-oriented saturated furan rings. Intermediate for pharmaceuticals. Combustible.
Trademarks
Ismotic (Alcon).
Biologische Funktion
emergency treatment of acute angle-closure glaucoma. It should not be confused with isosorbide dinitrate, an antianginal drug.
Flammability and Explosibility
Non flammable
Clinical Use
Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its ophthalmologic properties are its primary value.

Isosorbide Upstream-Materialien And Downstream Produkte

1,4:3,6-Dianhydro-D-glucitol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

652-67-5, Isosorbide Verwandte Suche:

Send Inquriy