Isosorbidmononitrat

Bezeichnung:Isosorbidmononitrat

CAS-Nr16051-77-7

Englisch Name:Isosorbide 5-mononitrate

CBNumberCB3256697

SummenformelC6H9NO6

Molgewicht191.14

MOL-Datei16051-77-7.mol

Synonyma

Isosorbidmononitrat

Isosorbidmononitrat physikalisch-chemischer Eigenschaften

Schmelzpunkt	88-93 °C
alpha	170 º (c=1, EtOH)
Siedepunkt	326.86°C (rough estimate)
Dichte	1.5784 (rough estimate)
Brechungsindex	145 ° (C=5, H2O)
storage temp.	-20°C Freezer
Löslichkeit	Undiluted isosorbide mononitrate is freely soluble in water, in acetone, in ethanol (96 per cent) and in methylene chloride. The solubility of the diluted product depends on the diluent and its concentration.
Aggregatzustand	Solid
pka	13.09±0.40(Predicted)
Farbe	White to Off-White
Wasserlöslichkeit	soluble
Merck	5225
InChIKey	YWXYYJSYQOXTPL-SLPGGIOYSA-N
CAS Datenbank	16051-77-7(CAS DataBase Reference)
EPA chemische Informationen	D-Glucitol, 1,4:3,6-dianhydro-, 5-nitrate (16051-77-7)

Sicherheit

Kennzeichnung gefährlicher	Xi-F,Xi,F
R-Sätze:	36/37/38-11
S-Sätze:	37/39-16-15
RIDADR	3251
RTECS-Nr.	LZ4386500
HazardClass	4.1
HS Code	2932999000
Toxizität	LD50 oral in rat: 2010mg/kg

Gefahreninformationscode (GHS)

Isosorbide 5-mononitrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S15:Vor Hitze schützen.
Chemische Eigenschaften
white to light yellow crystal powde
Verwenden
Isosorbide 5-Mononitrate is a metabolite of Isosorbide Dinitrate; used as an antianginal.
Verwenden
antidepressant, 5HT reuptake inhibitor
Verwenden
A metabolite of Isosorbide Dinitrate. Used as an antianginal
Definition
ChEBI: Isosorbide mononitrate is a nitrate ester and a glucitol derivative. It has a role as a nitric oxide donor and a vasodilator agent.
Trademarks
Imdur (Schering-Plough); Ismo (Dr. Reddy’s); Monoket (Schwarz Pharma) .
Allgemeine Beschreibung
Isosorbide 5-mononitrate is a crystalline solid. Isosorbide 5-mononitrate is very flammable and may be toxic by ingestion.
Air & Water Reaktionen
Highly flammable.
Reaktivität anzeigen
The dinitrate, a heart drug, can detonate when dry, but is non explosive with 30% of water [J. Haz.. Mater., 1992, 32(1), 87]. The mononitrate would be expected to be less reactive.
Health Hazard
Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.
Brandgefahr
Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.
Clinical Use
Vasodilator:
Treatment and prophylaxis of angina
Adjunct in congestive heart failure

Isosorbide 5-mononitrate Upstream-Materialien And Downstream Produkte

Isosorbidmononitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

16051-77-7, Isosorbide 5-mononitrate Verwandte Suche:

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