Uridin-2',3',5'-triacetat

2',3',5'-Tri-O-acetyluridine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Uridine triacetate is an orally available pro-drug of uridine approved by the FDA for the treatment of the rare autosomal recessive disorder called hereditary orotic aciduria. The drug was also approved for treating overdose of two chemotherapies (fluorouracil and capecitabine). Uridine triacetate was developed by Wellstat Therapeutics and licensed to BTG.

• Chemische Eigenschaften

  White or almost white crystalline powder

• Verwenden

  2’,3’,5’-Triacetyluridine is used in the treatment of Alzheimer’s disease in mice and provide neuroprotective effects. Shown to also decrease depressive symptoms and increases in brain pH bipolar patients.

• Definition

  ChEBI: Uridine triacetate is an acetate ester that is uracil in which the three hydroxy hydrogens are replaced by acetate group. A prodrug for uridine, it is used for the treatment of hereditary orotic aciduria and for management of fluorouracil toxicity. It has a role as a prodrug, a neuroprotective agent and an orphan drug. It is a member of uridines and an acetate ester.

• Synthese

  Commercially available uridine (167) was treated with acetic anhydride in the presence of catalytic boron trifluoride-etherate, and the crude product was recrystallized from ethanol to give uridine triacetate (XX) in 74-78% yield.
  

2',3',5'-Tri-O-acetyluridine Upstream-Materialien And Downstream Produkte

Uridin-2',3',5'-triacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(310)Suppliers

4105-38-8, 2',3',5'-Tri-O-acetyluridine Verwandte Suche: