2'-Desoxyuridin

Bezeichnung:2'-Desoxyuridin

CAS-Nr951-78-0

Englisch Name:2'-Deoxyuridine

CBNumberCB3472057

SummenformelC9H12N2O5

Molgewicht228.2

MOL-Datei951-78-0.mol

Synonyma

2'-Desoxyuridin

2'-Desoxyuridin physikalisch-chemischer Eigenschaften

Schmelzpunkt	167-169 °C(lit.)
Siedepunkt	370.01°C (rough estimate)
alpha	D22 +50° (c = 1.1 in N NaOH)
Dichte	1.3705 (rough estimate)
Brechungsindex	52 ° (C=1, 1mol/L NaOH)
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
pka	pKa 9.3(H2O t = 25) (Uncertain)
Aggregatzustand	Powder
Farbe	White to off-white
Wasserlöslichkeit	300 g/L (20 ºC)
Sensitive	Air Sensitive
Merck	14,2910
BRN	24433
InChIKey	MXHRCPNRJAMMIM-ATRFCDNQSA-N
CAS Datenbank	951-78-0(CAS DataBase Reference)
EPA chemische Informationen	Uridine, 2'-deoxy- (951-78-0)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38
S-Sätze:	22-24/25-37/39-36/37/39-26
WGK Germany	3
RTECS-Nr.	YU7490000
F	10-23
Hazard Note	Air Sensitive
TSCA	Yes
HS Code	29349990

Gefahreninformationscode (GHS)

2'-Deoxyuridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
2'-Deoxyuridine is an intermediate in the synthesis of thymidylate, which is a precursor for DNA synthesis. It has been shown to inhibit the enzymatic activity of enzymes responsible for synthesizing uridine and thymidylate, leading to neuronal death. 2'-Deoxyuridine has been used as a fluorescence probe for nucleic acids and as a polymerase chain reaction (PCR) substrate. It is also known to bind with toll-like receptor 4 (TLR4), which is involved in inflammatory responses.
Chemische Eigenschaften
White crystalline powder
Verwenden
2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2'-Deoxyuridines used as labeling substrates include chloro-2'-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2'-deoxyuridine include 5-ethynyl-2'-deoxyuridine (DdU) and 5-hydroxymethyl-2'-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.
Verwenden
An uridine derivative as therapeutic agent for treating allergy, cancer, infection and autoimmune disease
Definition
ChEBI: 2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside having uracil as the nucleobase. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a uracil.
Biologische Aktivität
2'-deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of dna synthesis and degradation mechanisms.

2'-Deoxyuridine Upstream-Materialien And Downstream Produkte

2'-Desoxyuridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

951-78-0, 2'-Deoxyuridine Verwandte Suche:

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