Triamteren Produkt Beschreibung

Triamterene Struktur
396-01-0
  • CAS-Nr.396-01-0
  • Bezeichnung:Triamteren
  • Englisch Name:Triamterene
  • Synonyma:Triamteren
    dytac;ditak;diren;dyren;teriam;diurene;ADEMINE;noridil;noridyl;skf8542
  • CBNumber:CB0663775
  • Summenformel:C12H11N7
  • Molgewicht:253.26
  • MOL-Datei:396-01-0.mol
Triamteren physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :316°C
  • Siedepunkt: :386.46°C (rough estimate)
  • Dichte :1.3215 (rough estimate)
  • Brechungsindex :1.8260 (estimate)
  • Flammpunkt: :11 °C
  • storage temp.  :2-8°C
  • Löslichkeit :formic acid: soluble200 mg + 4 mL warm Formic Acid, clear, yellow-green
  • pka :6.2(at 25℃)
  • Aggregatzustand :neat
  • Wasserlöslichkeit :<0.1 G/100 ML AT 20 ºC
  • Merck  :14,9599
  • BRN  :266723
  • InChIKey :FNYLWPVRPXGIIP-UHFFFAOYSA-N
  • CAS Datenbank :396-01-0(CAS DataBase Reference)
  • NIST chemische Informationen :Triamterene(396-01-0)
  • EPA chemische Informationen :2,4,7-Pteridinetriamine, 6-phenyl-(396-01-0)
Sicherheit

Triamterene Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R36/38:Reizt die Augen und die Haut.
    R23/25:Giftig beim Einatmen und Verschlucken.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S33:Maßnahmen gegen elektrostatische Aufladungen treffen.
    S24:Berührung mit der Haut vermeiden.
    S16:Von Zündquellen fernhalten - Nicht rauchen.
    S7:Behälter dicht geschlossen halten.
  • Chemische Eigenschaften Yellow Solid
  • Verwenden Triamterene is a potassium-sparing diuretic ie, it inhibits the urinary excretion of potassium
  • Verwenden Triamterene is a weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.
  • Biologische Funktion Triamterene (Dyrenium) results in changes in urinary electrolyte patterns that are qualitatively similar to those produced by spironolactone. The mechanism by which this agents bring about the alterations in electrolyte loss, however, is quite different. Triamterene produces this effects whether or not aldosterone or any other mineralocorticoid is present. The action of this drug is clearly unrelated to endogenous mineralocorticoid activity, and this drug is effective in adrenalectomized patients.
  • Allgemeine Beschreibung Odorless yellow powder or crystalline solid. Melting point 316°C. Almost tasteless at first and with a slightly bitter aftertaste. Acidified solutions give a blue fluorescence. Used as a diuretic drug.
  • Air & Water Reaktionen Sensitive to light; slowly oxidized upon exposure to air. Insoluble in water.
  • Reaktivität anzeigen 2,4,7-Triamino-6-phenylpteridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
  • Brandgefahr Flash point data for 2,4,7-Triamino-6-phenylpteridine are not available; however, 2,4,7-Triamino-6-phenylpteridine is probably combustible.
  • Clinical Use Triamterene can be used in the treatment of congestive heart failure, cirrhosis, and the edema caused by secondary hyperaldosteronism. It is frequently used in combination with other diuretics except spironolactone. Amiloride, but not triamterene, possesses antihypertensive effects that can add to those of the thiazides. These K+-sparing diuretics have low efficacy when used alone, since only a small amount of total Na reabsorption occurs at more distal sites of the nephron.
    These compounds are used primarily in combination with other diuretics, such as the thiazides and loop diuretics, to prevent or correct hypokalemia. The availability of fixed-dose mixtures of thiazides with nonsteroidal K+-sparing compounds has proved a rational form of drug therapy. Both triamterene and amiloride are available alone or in combination with hydrochlorothiazide.
  • Nebenwirkungen Because the actions of triamterene and amiloride are independent of plasma aldosterone levels, their prolonged administration is likely to result in hyperkalemia. Both amiloride and triamterene are contraindicated in patients with hyperkalemia.Triamterene should not be given to patients with impaired renal function. Potassium intake must be reduced, especially in outpatients.A folic acid deficiency has been reported to occur occasionally following the use of triamterene.
  • Veterinary Drugs and Treatments Triamterene is a potassium-sparing diuretic that potentially could be used as an alternative to spironolactone for the adjunctive treatment of congestive heart failure in dogs, however, there is little experience associated with its use in dogs or cats.
Triamterene Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Triamteren Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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396-01-0, Triamterene Verwandte Suche:
  • 7-pteridinetriamine,6-phenyl-4
  • diren
  • ditak
  • diurene
  • dyren
  • dyrenium
  • dytac
  • jatropur
  • 6-Phenyl-
  • Ademine(Triamterene)
  • Triamterene Solution, 1000ppm
  • Triamterene Solution, 100ppm
  • 6-PHENYL-PTERIDINE-2,4,7-TRIAMINE
  • 6-PHENYL-2,4,7-PTERIDINETRIAMINE
  • 6-PHENYL-2,4,7-TRIAMINO PTERIDINE
  • ADEMINE
  • 2,4,7-TRIAMINO-6-PHENYLPTERIDINE
  • TRIAMTERENE
  • 2,4,7-triamino-6-fenilpteridina
  • 2,4,7-triamino-6-phenyl-pteridin
  • ncic56042
  • noridil
  • noridyl
  • pterofen
  • pterophene
  • skf8542
  • taturil
  • teriam
  • teridin
  • triampur
  • triamteren
  • triamteril
  • triamterilcomplex
  • tri-span
  • triteren
  • TRIAMTERENE SODIUM CHANNEL BLOCKE
  • TRIAMTERENUM
  • 2,4,7-Pteridinetriamine, 6-phenyl-
  • TRIAMTERENE,USP
  • PTERIDINE,2,4,7-TRIAMINO-6-PHENYL-
  • 6-PHENYL-2,4,7-TRIAMINOPTERIDINE (SEE 1843)
  • 2,4,7-Triamino-6-phenylteridine
  • (2,4-diamino-6-phenyl-pteridin-7-yl)amine
  • Triamterene,2,4,7-Triamino-6-phenylpteridine
  • Triamterene (200 mg)
  • 396-01-0
  • C12H11N7
  • Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Voltage-gated Ion Channels
  • Sodium Channel Modulators
  • Ion Channels
  • Other Sodium Channel Modulators
  • Monovalent Ion Channels
  • AMINE
  • Nucleotides