1-Acetyl-L-prolin

Bezeichnung:1-Acetyl-L-prolin

CAS-Nr68-95-1

Englisch Name:N-Acetyl-L-proline

CBNumberCB0481658

SummenformelC7H11NO3

Molgewicht157.17

MOL-Datei68-95-1.mol

Synonyma

1-Acetyl-L-prolin

1-Acetyl-L-prolin physikalisch-chemischer Eigenschaften

Schmelzpunkt	115-117 °C
alpha	-86 º (c=1 EtOH)
Siedepunkt	366.2±35.0 °C(Predicted)
Dichte	1.274±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand	Powder
pka	3.69±0.20(Predicted)
Farbe	White to off-white
BRN	83200
InChI	InChI=1S/C7H11NO3/c1-5(9)8-4-2-3-6(8)7(10)11/h6H,2-4H2,1H3,(H,10,11)/t6-/m0/s1
InChIKey	GNMSLDIYJOSUSW-LURJTMIESA-N
SMILES	C(O)(=O)[C@@H]1CCCN1C(C)=O
CAS Datenbank	68-95-1(CAS DataBase Reference)
NIST chemische Informationen	L-proline, 1-acetyl-(68-95-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
S-Sätze:	24/25
WGK Germany	3
HazardClass	IRRITANT
HS Code	29339900

Gefahreninformationscode (GHS)

N-Acetyl-L-proline Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to off-white powder
Verwenden
N-Acetyl-L-proline is an aminoacid used in the synthesis of pharmaceutical compounds useful in preventing and treating disorders and syndromes associated with the nervous, vascular, musculoskeletal, o r cutaneous systems.
Definition
ChEBI: N-acetyl-L-proline is a N-acetyl-L-amino acid, a N-acylpyrrolidine, a pyrrolidinemonocarboxylic acid and a L-proline derivative.
Biochem/physiol Actions
N-acetyl-L-proline is an analog of the COOH-terminal dipeptide portion of preferred substrates of angiotensin-converting enzyme (ACE). It may be used in studies of the binding of substrates and inhibitors by ACE and to differentiate the specificities of various aminoacylases.
Einzelnachweise
[1] Jingxuan Qiu. “Solubility Behavior and Polymorphism of N-Acetyl-l-proline in 16 Individual Solvents from 283.15 to 323.15 K.” Journal of Chemical & Engineering Data 66 3 (2021): 1533–1542.
Beschreibung
N-Acetyl-L-proline (NALP) is an N-acetyl derivative of L-proline, which has wide application in medicine and is commonly utilized as a biologically active supplement. It can also act as an intermediate for synthesizing pharmaceuticals for preventing and treating some disorders and syndromes associated with the nervous, vascular, musculoskeletal, or cutaneous systems. In laboratories, it could play the role of a simple model for the secondary structure of proline-containing peptides. NALP can be acetylated from L-proline via a standard method, in the environment of acetic acid, or by the action of acetic anhydride on aqueous solutions of the products of the alkaline hydrolysis of gelatin followed by extraction. However, these methods may result in the production of many byproducts[1].

1-Acetyl-L-prolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

68-95-1, N-Acetyl-L-proline Verwandte Suche:

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