O-Phosphoserin

Bezeichnung:O-Phosphoserin

CAS-Nr407-41-0

Englisch Name:O-Phospho-L-serine

CBNumberCB0456205

SummenformelC3H8NO6P

Molgewicht185.07

MOL-Datei407-41-0.mol

Synonyma

O-Phosphoserin

O-Phosphoserin physikalisch-chemischer Eigenschaften

Schmelzpunkt	190 °C(lit.)
alpha	[α]D20 +14～+18°(c=5,dil.HCl)
Siedepunkt	475.4±55.0 °C(Predicted)
Dichte	1.809±0.06 g/cm3(Predicted)
Dampfdruck	0Pa at 20℃
storage temp.	under inert gas
Löslichkeit	H₂O: 50 mg/mL hot, clear, colorless to slightly yellow
Aggregatzustand	Crystalline Powder
pka	pK1:2.08;pK2:5.65;pK3:9.74 (25°C)
Farbe	White
Optische Aktivität	+16.221 (2 mol dm-3 HCl)
Wasserlöslichkeit	28.34g/L at 20℃
Merck	14,7363
BRN	1726826
InChIKey	BZQFBWGGLXLEPQ-UWTATZPHSA-N
CAS Datenbank	407-41-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	21/22
S-Sätze:	36/37
RIDADR	UN 3261 8 / PGII
WGK Germany	3
F	10
HS Code	29225090

Gefahreninformationscode (GHS)

O-Phospho-L-serine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC₅₀s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.
Chemische Eigenschaften
White powder
Verwenden
roborant
Verwenden
O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.
Verwenden
L-O-Phosphoserine is the catalytic domain of human protein kinase C β II when complexed with a malemide inhibitor. It is also used in the purification of the Epstein-Barr virus nuclear antigen 2A.
Definition
ChEBI: O-phospho-L-serine is the L-enantiomer of O-phosphoserine. It has a role as an EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, an EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor, an EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor and a mouse metabolite. It is a conjugate acid of an O-phosphonato-L-serine(2-). It is an enantiomer of an O-phospho-D-serine.
Allgemeine Beschreibung
Monoclonal Anti-Phosphoserine (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Flammability and Explosibility
Not classified
Biologische Aktivität
Group III metabotropic glutamate receptor agonist; analog of L-AP4 (L-(+)-2-Amino-4-phosphonobutyric acid ). Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
Biochem/physiol Actions
Protein phosphorylation and dephosphorylation are basic signaling mechanisms that modify protein function in eukaryotic cells. Phosphorylation is a rare posttranslational event in normal tissues, however, the abundance of phosphorylated cellular proteins increases several folds following various activation processes. The main amino acids that are phosphorylated are tyrosine, serine, or threonine (pTyr/pSer/pThr), each having specific kinases that phosphorylate them and specific phosphatases that dephosphorylate them. Mono and polyclonal antibodies directed against phosphorylated residues were generated and found useful as analytical and preparative tools by enabling the identification, quantification, and immunoaffinity isolation of phosphorylated cellular proteins.
Lager
Room temperature
läuterung methode
Recrystallise the phospho-serine by dissolving 10g in H2O (150mL) at 25o, stirring for up to 20minutes. Undissolved material is filtered off (Büchner), and 95% EtOH (85mL) is added dropwise during 4minutes, and set aside at 25o for 3hours, then at 3o overnight. The crystals are washed with 95% EtOH (100mL), then dry Et2O (50mL), and dried in a vacuum (yield 6.5g). A further quantity (1.5g) can be obtained by keeping the mother liquors and washings at -10o for 1 week. The DL-isomer has m 167-170o(dec) after recrystallisation from H2O/EtOH or MeOH. [Neuhaus & Korkes Biochemical Preparations 6 75 1958, Neuhaus & Byrne J Biol Chem 234 113 1959, IR: F.lsch & Mellander Acta Chem Scand 11 1232 1957, Beilstein 4 IV 3120.]

O-Phospho-L-serine Upstream-Materialien And Downstream Produkte

O-Phosphoserin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

407-41-0, O-Phospho-L-serine Verwandte Suche:

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