407-41-0
基本信息
右磷丝氨酸
L-O-磷酸丝氨酸
H-SER(PO3H2)-OH
H-SER(P)-OH
L-2-AMINO-3-HYDROXYPROPANOIC ACID 3-PHOSPHATE
L-O-PHOSPHOSERINE
L-PHOSPHOSERINE
L-SERINE-O-PHOSPHATE
O-PHOSPHO-L-SERINE
O-PHOSPHORYL-L-SERINE
PHOSPHOSERINE
PHOSPHOSERINE ANTIBODY INHIBITOR
SERINE(PO3H2)-OH
dexfosfoserine
L-(+)-serine 3-(dihydrogen phosphate)
L-Phosphoserine Anhydrous
Phosphoserinebariumsalt
O-phosphoserine
Serine phosphate
(2S)-2-amino-3-phosphonooxy-propanoic acid
L-O-(RG)
物理化学性质
| 熔点 | 190 °C(lit.) |
| 熔点 | 190 °C(lit.) |
| 比旋光度 | [α]D20 +14～+18°(c=5,dil.HCl) |
| 沸点 | 475.4±55.0 °C(Predicted) |
| 密度 | 1.809±0.06 g/cm3(Predicted) |
| 蒸气压 | 0Pa at 20℃ |
| 储存条件 | Store at 0°C |
| 储存条件 | under inert gas |
| 溶解度 | H2O: 50 mg/mL hot, clear, colorless to slightly yellow |
| 溶解度 | H2O：50 mg/mL 热，透明，无色至浅黄色 |
| 酸度系数(pKa) | pK1:2.08;pK2:5.65;pK3:9.74 (25°C) |
| 形态 | 结晶粉末 |
| 颜色 | 白色 |
| 生物来源 | mouse |
| 旋光度 (Optical Rotation) | +16.221 (2 mol dm-3 HCl) |
| 水溶解性 | 28.34g/L at 20℃ |
| Merck | 14,7363 |
| Merck | 7363 |
| BRN | 1726826 |
| 化妆品成分功效 | SKIN CONDITIONING HAIR CONDITIONING |
| InChI | 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 |
| InChIKey | BZQFBWGGLXLEPQ-UWTATZPHSA-N |
| SMILES | N[C@@H](COP(O)(O)=O)C(O)=O |
| CAS 数据库 | 407-41-0(CAS DataBase Reference) |
安全数据
| 危险性符号(GHS) |  GHS05 |
| 警示词 | 危险 |
| 危险性描述 | H314 |
| 防范说明 | P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| 危险品标志 | Xn |
| 危险类别码 | 21/22 |
| 安全说明 | 36/37 |
| 危险品运输编号 | UN 3261 8 / PGII |
| WGK Germany | 3 |
| WGK Germany | 3 |
| F | 10 |
| REACH 注册登记 | Active |
| 海关编码 | 29225090 |
| 存储类别 | 8B - Non-combustible corrosive hazardous materials |
| 危险性类别 | Skin Corr. 1B |
知名试剂公司产品信息
L-O-Phosphoserine,>98.0%(T)(407-41-0) TCI Shanghai
L-O-磷酸丝氨酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-15129R | L-O-磷酸丝氨酸 O-Phospho-L-serine (Standard) | 407-41-0 | 10 mg | 370元 |
| 2026/09/15 | HY-15129 | L-O-磷酸丝氨酸 O-Phospho-L-serine | 407-41-0 | 25 mg | 185元 |
| 2026/09/15 | HY-15129R | L-O-磷酸丝氨酸 O-Phospho-L-serine (Standard) | 407-41-0 | 25 mg | 670元 |
常见问题列表
| Target | Value |
|
mGluR
() |
O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a K i of 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a K i of 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gα i/o proteins. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina.