Flomoxef

Bezeichnung:Flomoxef

CAS-Nr99665-00-6

Englisch Name:Flomoxef

CBNumberCB0328847

SummenformelC15H18F2N6O7S2

Molgewicht496.47

MOL-Datei99665-00-6.mol

Flomoxef physikalisch-chemischer Eigenschaften

Schmelzpunkt	82.5-87.5°
Dichte	1.85±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	soluble in DMSO, Methanol
Aggregatzustand	Solid
pka	3.26±0.40(Predicted)
Farbe	Off-White
CAS Datenbank	99665-00-6(CAS DataBase Reference)

Flomoxef Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Flomoxef sodium is a P-lactamase resistant oxacephalosporin. Its spectrum of activity is similar to that of cefazolin and moxalactam, but with better efficacy against Staphylococcus aureus and Bacteroides fragilis. Flomoxef is reported effective in the treatment of post-operative, urinary tract and abdominal cavity infections.
Originator
Shionogi (Japan)
Verwenden
Flomoxef is an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.
Definition
ChEBI: Flomoxef is a second-generation oxacephem antibiotic in which the oxazine ring is substituted at C-3 with a hydroxyethyl-substituted tetrazolylthiomethyl group and the azetidinone ring carries 7alpha-methoxy and 7beta-{2-[(difluoromethyl)thiomethyl]acetamido} substituents. It has a role as an antibacterial drug. It is a N-acyl-amino acid, an oxacephem and an organonitrogen heterocyclic antibiotic.
Trademarks
Flumari
Antimicrobial activity
An oxa-cephem which differs from latamoxef in the side chains carried at the 7-amino and C-3 positions, but which retains the 7-methoxy group that confers β-lactamase stability. The methyl group of the methylthiotetrazole side chain of latamoxef has been modified to hydroxymethyl in an attempt to avoid the undesirable side effects, while the side chain at the 7-amino position is F2-CH-S-CH2-.
Activity is similar to that of latamoxef, but activity against Staph. aureus is improved and it is claimed to be a poor inducer of penicillin-binding protein 2′, which is associated with resistance in methicillin-resistant strains.
Intravenous injection of 2 g achieves a peak plasma concentration of around 50 mg/L, falling to 2.6 mg/L after 6 h. The plasma half-life is about 50 min. It appears to be well distributed and penetrates moderately well into lung, mucosal tissue of the middle ear and bone.
Flomoxef does not seem to be prone to the effects on platelet function of latamoxef and it has a less marked effect on vitamin K metabolism. It does not cause a disulfiram-like reaction with alcohol.
It is available in Japan, where it appears safe and effective in a wide range of infections.

Flomoxef Upstream-Materialien And Downstream Produkte

Flomoxef Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

99665-00-6, Flomoxef Verwandte Suche:

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