Dinatriumdihydrogen(dichloromethylen)diphosphonat

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Clodronate disodium Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Clodronate disodium is a bone resorption inhibitor, useful as adjunct therapy in the treatment of osteolytic bone metastases and malignant hypercalcemia.

• Chemische Eigenschaften

  White Solid

• Originator

  Proctor & Gamble (USA)

• Verwenden

  Clodronic Acid Disodium Salt Hydrate is a bisphosphonate antiresorptive agent; bone resorption inhibitor.

• Definition

  ChEBI: The disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used (generally as the tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteoly ic lesions and bone pain associated with skeletal metastases.

• Trademarks

  Bonefos (Leiras Oy, Finland).

• Hazard

  Moderately toxic by ingestion.

• Biochem/physiol Actions

  Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

• Clinical Use

  Bisphosphonate: Management of osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastases in patients with breast cancer or multiple myeloma

• Sicherheitsprofil

  A poison by intravenous route. Moderately toxic by ingestion, intraperitoneal routes. When heated to decomposition it emits toxic vapors of PO, and Cl-

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Cytotoxics: concentration of estramustine increased.

• Stoffwechsel

  Clodronate is not metabolised.
  Over 70% of an intravenous dose is excreted unchanged in the urine within 24 hours, the remainder being sequestered to bone tissue. The substance which is bound to bone is excreted more slowly, and the renal clearance is about 75% of the plasma clearance.

Dinatriumdihydrogen(dichloromethylen)diphosphonat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(166)Suppliers

22560-50-5, Clodronate disodium Verwandte Suche: