TriMethyl(broModifluoroMethyl)silane

Bezeichnung:TriMethyl(broModifluoroMethyl)silane

CAS-Nr115262-01-6

Englisch Name:TriMethyl(broModifluoroMethyl)silane

CBNumberCB02611493

SummenformelC4H9BrF2Si

Molgewicht203.1

MOL-Datei115262-01-6.mol

TriMethyl(broModifluoroMethyl)silane physikalisch-chemischer Eigenschaften

Siedepunkt	108°C(lit.)
Dichte	1.306
Brechungsindex	n/D1.407
Flammpunkt	46℃
storage temp.	-20°C
Aggregatzustand	liquid
Farbe	clear
InChIKey	WDZVWBWAUSUTTO-UHFFFAOYSA-N
CAS Datenbank	115262-01-6

Sicherheit

R-Sätze:	11
S-Sätze:	24/25
RIDADR	UN 1993C 3 / PGIII
TSCA	No
HazardClass	3
PackingGroup	II
HS Code	29319090

Gefahreninformationscode (GHS)

TriMethyl(broModifluoroMethyl)silane Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Colorless transparent liquid, initial boiling point 108℃, relative density 1.31 g/cm³.
Verwenden
Novel difluorocarbene source for the efficient difluoromethylenation of alkenes/alkynes and difluoromethylation of O-, S-, and N-nucleophiles.
Verwenden
Trimethyl(bromodifluoromethyl)silane can be used as neuroactive steroids.
Verwenden
As reported by Hu and co-workers, (Bromodifluoromethyl)trimethylsilane is a highly useful reagent for the formation of difluoromethene-containing 3-membered rings and can also difluoromethylate heteroatoms with the assistance of alkaline bases, most effectively KOH.
Application
- TriMethyl(broModifluoroMethyl)silane commonly can be used as a source for generating difluorocarbene, it is a general reagent with broad synthetic utility.
- Can generate difluorocarbene under neutral/acidic/basic conditions in the presence/absence of water at low/high temperatures.
- Can be used to prepare gem-difluorocyclopropan(e)nes, O-, S-, N-, and P-difluoromethylated compounds
Reaktionen
(1) Difluoromethylenation of TMSCN.

Ref. J. Org. Chem. 2012, 77, 5850?5855.
(2) Difluoromethylenation of benzyl and alkylzinc halides.

Ref. Org. Lett. 2013, 15, 917 – 919.
(3) Fluorination aminocarbonylation of aldehydes

Ref. Angew. Chem. Int. Ed. 2022, e202115467
Allgemeine Beschreibung
(Bromodifluoromethyl)trimethylsilane (TMSCF₂Br) is commonly used as a source to generate dilfluorocarbene. TMSCF₃ (Ruppert–Prakash reagent) and BBr₃ undergoes fast halogen–exchange reaction to form MSCF₂Br.
Einzelnachweise
[1]Angewandte Chemie International Edition.DOI :10.1002/anie.202283811
[2]The Journal of Organic Chemistry.DOI :10.1021/acs.orglett.2c02899

TriMethyl(broModifluoroMethyl)silane Upstream-Materialien And Downstream Produkte

TriMethyl(broModifluoroMethyl)silane Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

115262-01-6, TriMethyl(broModifluoroMethyl)silane Verwandte Suche:

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