alpha-Cyclohexyl-alpha-hydroxyben-zolessigsäure-4-(diethylamino)-2-butinylester-hydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Oxybutynin hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.

• S-Sätze Betriebsanweisung:

  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Chemische Eigenschaften

  White to Off-White Solid

• Originator

  Ditropan, Marion , US ,1975

• Verwenden

  An antagonist of M1, M2, & M3 muscarinic acetylcholine receptors

• Verwenden

  anticholinergic

• Verwenden

  An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells

• Manufacturing Process

  A mixture of 394.2 grams of methyl phenylcyclohexylglycolate and 293.1 grams of 4-diethylamino-2-butynyl acetate was dissolved with warming in 2.6 liters of n-heptane. The solution was heated with stirring to a temperature of 60° to 70°C and 8.0 grams of sodium methoxide were added. The temperature of the mixture was then raised until the solvent began to distill. Distillation was continued at a gradual rate and aliquots of the distillate were successively collected and analyzed for the presence of methyl acetate by measurement of the refractive index. The reaction was completed when methyl acetate no longer distilled, and the refractive index observed was that of pure heptane (nD26 = 1.3855). About 3? hours were required for the reaction to be completed.
  The reaction mixture was then allowed to cool to room temperature, washed with water, and extracted with four 165 ml portions of 2 N hydrochloric acid. The aqueous extracts were combined and stirred at room temperature to permit crystallization of the hydrochloride salt of the desired product. Crystallization was completed by cooling the slurry in an ice bath, and the product was collected by filtration, pressed dry, and recrystallized from 750 ml of water. Yield of pure crystalline material, 323 grams.

• Trademarks

  Ditropan (ALZA).

• Therapeutic Function

  Spasmolytic

• Biologische Aktivität

  oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.

• Biochem/physiol Actions

  Muscarinic acetylcholine receptor antagonist; inhibits proliferation of bladder smooth muscle cells, perhaps by downregulation of growth promoting genes.

• Clinical Use

  Urinary frequency, urgency and incontinence
  Neurogenic bladder instability and nocturnal enuresis

• Sicherheitsprofil

  Poison by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. An eye irritant. Human systemic effects: coma, mydriasis, rate changes. An anticholinergic agent. When heated to decomposition it e

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.
  Other antimuscarinic agents: increased antimuscarinic effects.

• Stoffwechsel

  Oxybutynin undergoes extensive first-pass metabolism, particularly by the cytochrome P450 isoenzyme
  CYP3A4. One of the metabolites, N-desethyloxybutynin is pharmacologically active.
  Oxybutynin and its metabolites are excreted in the urine and faeces.

Oxybutynin hydrochloride Upstream-Materialien And Downstream Produkte

alpha-Cyclohexyl-alpha-hydroxyben-zolessigsäure-4-(diethylamino)-2-butinylester-hydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(341)Suppliers

1508-65-2, Oxybutynin hydrochloride Verwandte Suche: