CKD-602 盐酸盐
- CAS号:213819-48-8
- 英文名:Camtobell hydrochloride
- 中文名:CKD-602 盐酸盐
- CBNumber:CB81011157
- 分子式:C25H28ClN3O4
- 分子量:469.97
- MOL File:213819-48-8.mol
- 熔点 :>218°C (dec.)
- 储存条件 :under inert gas (nitrogen or Argon) at 2-8°C
- 溶解度 :DMSO (Slightly), Methanol (Slightly, heated), Water (Slightly)
- 形态 :Solid
- 颜色 :Pale Beige to Light Brown
CKD-602 盐酸盐性质、用途与生产工艺
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用途
CKD-602 盐酸盐是一种新型喜树碱衍生物抗肿瘤药物。尽管ckd -602在临床中应用更广泛，但静脉输注引起的ckd -602相关毒性尚未得到评估。
- 生物活性 Belotecan (CKD-602)是有效的DNA topoisomerase I抑制剂，可对多种类型的肿瘤发挥抗癌活性。
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靶点
Target Value DNA topoisomerase I
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体外研究
Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC 50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC 50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.
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体内研究
Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.
- 更新日期：2024/11/08
- 产品编号：HY-13566A
- 产品名称：Belotecan hydrochloride
- CAS编号：
- 包装：1 mg
- 价格：548元
- 更新日期：2024/11/08
- 产品编号：HY-13566A
- 产品名称：CKD-602 盐酸盐 Belotecan hydrochloride
- CAS编号：213819-48-8
- 包装：5mg
- 价格：1200元
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
