D-谷氨酸
- CAS号:6893-26-1
- 英文名:D(-)-Glutamic acid
- 中文名:D-谷氨酸
- CBNumber:CB6195447
- 分子式:C5H9NO4
- 分子量:147.13
- MOL File:6893-26-1.mol
- 熔点 :200-202 °C (subl.)(lit.)
- 比旋光度 :-31.3 º (c=10, 2 N HCl)
- 沸点 :267.21°C (rough estimate)
- 密度 :1.5380
- 折射率 :1.4210 (estimate)
- 储存条件 :Keep in dark place,Sealed in dry,Room Temperature
- 溶解度 :Water (Slightly)
- 形态 :Powder
- 酸度系数(pKa) :pK1:2.162(＋1);pK2:4.272(0);pK3:9.358(－1) (25°C)
- 颜色 :White to off-white
- 水溶解性 :7 g/L (20 ºC)
- Merck :14,4469
- BRN :1723800
- InChIKey :WHUUTDBJXJRKMK-GSVOUGTGSA-N
- LogP :-0.969 (est)
- CAS 数据库 :6893-26-1(CAS DataBase Reference)
- NIST化学物质信息 :D-Glutamic acid(6893-26-1)
- EPA化学物质信息 :D-Glutamic acid (6893-26-1)
- 危险品标志 :Xi
- 危险类别码 :36/37/38
- 安全说明 :24/25-36-26
- WGK Germany :3
- F :10
- TSCA :Yes
- 海关编码 :29224200
D-谷氨酸 MSDS
D-2-Aminoglutaric acid
D-谷氨酸性质、用途与生产工艺
- 生物活性 D-glutamic acid是L-glutamic acid的对映异构体，广泛用于药物和食品中。
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靶点
Human Endogenous Metabolite
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体外研究
Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens.
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体内研究
D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid.
- 化学性质 白色结晶或结晶性粉末；溶于水，微溶于乙醇，不溶于乙醚；比旋光度[α]20D-30.5°(0.5-2mg/ml，6mol/L HCl)，LD50(人，静脉) 117mg/kg。
- 用途 用于生化研究。
- 用途 氨基酸类药。
- 生产方法 以乙酰-DL-谷氨酸为原料，经酰化酶处理后去L-型，精制、干燥得产品。
- 更新日期：2024/11/08
- 产品编号：A14191
- 产品名称：D-谷氨酸, 99+% D-Glutamic acid, 99+%
- CAS编号：6893-26-1
- 包装：5g
- 价格：451元
- 更新日期：2024/11/08
- 产品编号：A14191
- 产品名称：D-谷氨酸, 99+% D-Glutamic acid, 99+%
- CAS编号：6893-26-1
- 包装：25g
- 价格：1407元
- 公司名称：DSM-CHIRAL
- 联系电话：--
- 电子邮件：ian.freelance@dsm.com
- 国家：荷兰
- 产品数：78
- 优势度：30
