盐酸阿地芬宁
- CAS号:50-42-0
- 英文名:Adiphenine hydrochloride
- 中文名:盐酸阿地芬宁
- CBNumber:CB5221596
- 分子式:C20H25NO2.ClH
- 分子量:347.88
- MOL File:50-42-0.mol
- 熔点 :113-114°
- 密度 :1.0555 (rough estimate)
- 折射率 :1.5400 (estimate)
- 储存条件 :Room Temperature
- 溶解度 :DMSO (Slightly), Methanol (Slightly), Water (Very Slightly)
- 形态 :Solid
- 颜色 :White
- Merck :14,161
- InChIKey :LKPINBXAWIMZCG-UHFFFAOYSA-N
- CAS 数据库 :50-42-0(CAS DataBase Reference)
盐酸阿地芬宁 MSDS
Diphenylacetic acid 2-(diethylamino)ethyl ester hydrochloride
盐酸阿地芬宁性质、用途与生产工艺
- 生物活性 Adiphenine HCl 是一种烟碱受体抑制剂，用作解痉药。
-
靶点
Target Value α3β4 nAChR
(Cell-free assay)1.8 μM α1 nAChR
(Cell-free assay)1.9 μM α4β2 nAChR
(Cell-free assay)3.7 μM α4β4 nAChR
(Cell-free assay)6.3 μM -
体外研究
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α1*-nAChR in a dose-dependent manner in TE671/RD cells, with an IC 50 of 1.9 µM.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α3α4*-nAChR in a dose-dependent manner in SH-SY5Y cells, with an IC 50 of 1.8 µM.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α4β2- and α4β4-nAChR in a dose-dependent manner in SH-EP1 cells, with IC 50 s of 3.7 and 6.3 µM, respectively.
Adiphenine (50-200 µM; 30-60 s) decreases the frequency of ACh-induced single-channel currents in HEK 293 cells. -
体内研究
Adiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED 50 of 62 mg/kg in mice.
- 更新日期：2024/11/08
- 产品编号：HY-B0379A
- 产品名称：盐酸阿地芬宁 Adiphenine hydrochloride
- CAS编号：50-42-0
- 包装：100mg
- 价格：200元
- 更新日期：2024/11/08
- 产品编号：HY-B0379A
- 产品名称：盐酸阿地芬宁 Adiphenine hydrochloride
- CAS编号：50-42-0
- 包装：10mM * 1mLin DMSO
- 价格：220元
- 公司名称：Medilom & Co.
- 联系电话：--
- 电子邮件：info@medilom.be
- 国家：比利时
- 产品数：563
- 优势度：58
