补骨脂定
- CAS号:18642-23-4
- 英文名:psoralidin
- 中文名:补骨脂定
- CBNumber:CB41384552
- 分子式:C20H16O5
- 分子量:336.34
- MOL File:18642-23-4.mol
- 熔点 :290-292°
- 沸点 :458.8±34.0 °C(Predicted)
- 密度 :1.383±0.06 g/cm3(Predicted)
- 储存条件 :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :DMSO: soluble5mg/mL, clear (warmed)
- 形态 :powder
- 酸度系数(pKa) :8.70±0.20(Predicted)
- 颜色 :white to beige
- InChIKey :YABIJLLNNFURIJ-UHFFFAOYSA-N
- WGK Germany :3
- 海关编码 :2932.20.4500
补骨脂定性质、用途与生产工艺
- 生物活性 Psoralidin 是从 Psoralea corylifolia 的种子中分离出来的，是 COX-2 和 5-LOX 的双重抑制剂。具有抗癌，抗菌和抗炎作用。Psoralidin 显著下调 NOTCH1 信号传导。Psoralidin 还极大地诱导 ROS 产生。
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靶点
COX-2
5-LOX
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体外研究
Three breast cancer cell (BCC)populations (ALDH - cells, ALDH + cells, and commercial BSCSs) are sensitive to Psoralidin treatment (10, 15, 20, and 25 μM; 24 hours) with IC 50 s ranging from 18 to 21 μM; however, the MCF-12A cells were resistant to Psoralidin.
Psoralidin (30 μM; 24 hours) results in a significant induction of apoptosis for ALDH - cells, ALDH + cells, and commercial BCSCs.
Psoralidin treatment also downregulates NOTCH1 expression in both ALDH - and ALDH + cells.Cell Viability Assay
Cell Line: ALDH - cells, ALDH + cells, commercial breast cancer stem cells (BSCSs), and normal breast epithelial cells (MCF-12A) Concentration: 10, 15, 50, and 25 μM Incubation Time: 24 hours Result: IC 50 s of 18 to 21 μM for ALDH - cells, ALDH + cells, commercial BCSCs. Apoptosis Analysis
Cell Line: ALDH - cells, ALDH + cells, and commercial BCSCs Concentration: 20 and 30 μM Incubation Time: 24 hours Result: No significant induction of apoptosis was observed for any of the three cell types following treatment at 20 μM. However, 53.60%, 44.1%, and 45.9% of cells were apoptotic at 30 μMin ALDH - cells, ALDH + cells, and commercial BCSCs, respectively. -
体内研究
Psoralidin (5 mg/kg) regulates expression of pro-inflammatory cytokines that play an important role in inflammatory diseasesin IR-irradiated lung of BALB/c mouse.
Animal Model: BALB/c mice Dosage: 5 mg/kg Administration: Intraperitoneal application; 30 min before and 1 h after IR irradiation (20 Gy). Result: Anti-inflammatory effect in IR-irradiated mice. - 化学性质 淡黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于补骨脂Psoralea corylifolia Linn.种子。
- 用途 补骨脂定具有抗真菌，细胞毒，扩张冠状动脉、止血的作用。
- 用途 一种ptp1b抑制剂，具有多种抗癌作用机制。
- 更新日期：2024/11/08
- 产品编号：HY-N0232
- 产品名称：补骨脂定 Psoralidin
- CAS编号：18642-23-4
- 包装：5mg
- 价格：600元
- 更新日期：2024/11/08
- 产品编号：HY-N0232
- 产品名称：补骨脂定 Psoralidin
- CAS编号：
- 包装：10 mM * 1 mLin DMSO
- 价格：660元
- 公司名称：AXXORA, LLC
- 联系电话：--
- 电子邮件：alexis-ch@alexis-corp.com
- 国家：瑞士
- 产品数：1104
- 优势度：80
