ChemicalBook CAS数据库列表 盐酸艾替伏辛
盐酸艾替伏辛
- CAS号:56776-32-0
- 英文名:6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride
- 中文名:盐酸艾替伏辛
- CBNumber:CB3883790
- 分子式:C17H18Cl2N2O
- 分子量:337.24362
- MOL File:56776-32-0.mol
盐酸艾替伏辛化学性质
- 熔点 :ND
- 储存条件 :-20°C
- 溶解度 :DMSO: ≥5mg/mL
- 形态 :powder
- 颜色 :white to beige
- 稳定性 :Hygroscopic
安全信息
盐酸艾替伏辛性质、用途与生产工艺
- 生物活性 Etifoxine hydrochloride是一个非苯二氮卓类的、具有 GABA 能的化合物，是 GABAA 受体亚基 α1β2γ2 和 α1β3γ2 的阳性变构调节剂。Etifoxine hydrochloride 在啮齿类动物中显示出抗焦虑和抗惊厥活性。
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体外研究
Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX.
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体内研究
Etifoxine competitively inhibits [ 35 S]TBPS binding with micromolar potency in rat brain.
Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice.
Animal Model: Six-week old BALB/cByJ and C57BL/6J mice (20-25 g). Dosage: 3.125-50 mg/kg. Administration: Intraperitoneal inhection. Result: Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice.
BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower plasma levels of the compound at 15 and 30 min.
盐酸艾替伏辛上下游产品信息
上游原料
下游产品
盐酸艾替伏辛 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-16579
- 产品名称：盐酸艾替伏辛 Etifoxine hydrochloride
- CAS编号：56776-32-0
- 包装：5mg
- 价格：700元
- 更新日期：2024/11/08
- 产品编号：HY-16579
- 产品名称：盐酸艾替伏辛 Etifoxine hydrochloride
- CAS编号：56776-32-0
- 包装：10mM * 1mLin DMSO
- 价格：770元
盐酸艾替伏辛生产厂家
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
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