D-谷氨酰胺
- CAS号:5959-95-5
- 英文名:D-Glutamine
- 中文名:D-谷氨酰胺
- CBNumber:CB3472365
- 分子式:C5H10N2O3
- 分子量:146.14
- MOL File:5959-95-5.mol
- 熔点 :184-185 °C
- 沸点 :265.74°C (rough estimate)
- 比旋光度 :-32 º (589nm, c=10, N HCl)
- 密度 :1.3394 (rough estimate)
- 折射率 :-33 ° (C=5, 5mol/L HCl)
- 储存条件 :Keep in dark place,Inert atmosphere,Room temperature
- 溶解度 :Water (Slightly, Sonicated)
- 酸度系数(pKa) :2.27±0.10(Predicted)
- 形态 :Powder
- 颜色 :White
- 水溶解性 :42.53g/L(temperature not stated)
- BRN :1723796
- InChIKey :ZDXPYRJPNDTMRX-GSVOUGTGSA-N
- LogP :-1.576 (est)
- CAS 数据库 :5959-95-5(CAS DataBase Reference)
- 危险品标志 :Xi
- 危险类别码 :36/37/38
- 安全说明 :36/37/39-26-27-24/25
- WGK Germany :3
- 海关编码 :29241900
D-谷氨酰胺性质、用途与生产工艺
- 生物活性 D-Glutamine 是可渗透细胞的谷氨酰胺 (Glutamine) 的 D 型立体异构体。
-
靶点
Human Endogenous Metabolite
-
体外研究
Glutamine is a key amino acid in the central nervous system (CNS), playing an important role in the glutamate/GABA-Glutamine cycle (GGC). In the GGC,Glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools. D-Glutamine has been used to study its role in conferring protection against acetaldehyde-induced disruption of barrier function in Caco-2 cell monolayer. Role of L-Glutamine in the protection of intestinal epithelium from acetaldehyde-induced disruption of barrier function is evaluated in Caco-2 cell monolayer. L-Glutamine reduced the acetaldehyde-induced decrease in transepithelilal electrical resistance and increase in permeability to inulin and lipopolysaccharide in a time- and dose-dependent manner; D-Glutamine, L-aspargine, L-arginine, L-lysine, or L-alanine produced no significant protection. D-Glutamine also fails to influence the acetaldehyde-induced decrease in TER and increase in inulin flux. D-Glutamine or glutaminase inhibitor by themselves did not influence TER or inulin flux in control or acetaldehyde-treated cell monolayers. Lack of effect of D-Glutamine in protection from acetaldehyde indicates that the L-Glutamine-mediated protection is stereospecific.
- 用途 是一种药用氨基酸,用于治疗胃和十二指肠溃疡和幼儿智力低下等症,也是治疗白血病药物的中间体。
- 更新日期:2024/04/30
- 产品编号:C13516
- 产品名称:D-谷氨酰胺 D(-)-Glutamine, 98% 1GR
- CAS编号:5959-95-5
- 包装:1g
- 价格:1119元
- 更新日期:2024/04/30
- 产品编号:C13516
- 产品名称:D-谷氨酰胺 D(-)-Glutamine, 98% 1GR
- CAS编号:5959-95-5
- 包装:5g
- 价格:4776元
- 公司名称:TCI Chemicals (India) Pvt. Ltd.
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