S-布洛芬
- CAS号:51146-56-6
- 英文名:(S)-(+)-Ibuprofen
- 中文名:S-布洛芬
- CBNumber:CB0699655
- 分子式:C13H18O2
- 分子量:206.28
- MOL File:51146-56-6.mol
- 熔点 :49-53 °C(lit.)
- 比旋光度 :57 º (c=2, EtOH)
- 沸点 :285.14°C (rough estimate)
- 密度 :1.0364 (rough estimate)
- 折射率 :59 ° (C=2, EtOH)
- 闪点 :>230 °F
- 储存条件 :Sealed in dry,Room Temperature
- 溶解度 :45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.5 mg/mL
- 酸度系数(pKa) :4.41±0.10(Predicted)
- 形态 :solid
- 颜色 :white
- 旋光性 (optical activity) :[α]20/D +59°, c = 2 in ethanol
- 水溶解性 :insoluble
- BRN :3590022
- 稳定性 :Stable. Incompatible with strong oxidizing agents.
- InChIKey :HEFNNWSXXWATRW-JTQLQIEISA-N
- CAS 数据库 :51146-56-6(CAS DataBase Reference)
S-布洛芬性质、用途与生产工艺
- 生物活性 (S)-(+)-Ibuprofen ((S)-Ibuprofen)，一种 Ibuprofen 的 S(+)-对映异构体，是一种有效的 COX-1 和 COX-2 抑制剂，IC50 分别为 2.1μM 和 1.6 μM。(S)-(+)-Ibuprofen 具有止痛，抗炎，抗癌和退热作用。
-
靶点
COX-1
2.1 μM (IC 50 )
COX-2
1.6 μM (IC 50 )
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体外研究
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 0-1000 µM; 8 days) treatment reduces concentration dependently cell survival in both cell lines to a similar extent.
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 0-1000 µM; 20-72 hours) treatment causes a G0/G1 phase block as well as apoptosis.
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 900 µM; 4-72 hours) treatment shows a down regulation of cyclin A and B and an increase of the cell cycle inhibitory protein p27Kip-1.
(S)-(+)-Ibuprofen inhibits COX activity, thromboxane formation, and platelet aggregation.
(S)-(+)-Ibuprofen inhibits the activation of NF-κB in response to T-cell stimulation with an IC 50 of 61.7 μM.Cell Proliferation Assay
Cell Line: HCT-15 and HCA-7 cells Concentration: 0 µM, 200 µM, 400 µM, 600 µM, 700 µM, 800 µM, 900 µM, and 1000 µM Incubation Time: 8 days Result: Reduced concentration dependently cell survival in both cell lines to a similar extent. Cell Cycle Analysis
Cell Line: HCT-15 and HCA-7 cells Concentration: 0 µM, 200 µM, 400 µM, 600 µM, 800 µM, 900 µM, and 1000 µM Incubation Time: 24 hours (HCT-15) or 20 hours (HCA-7) Result: Caused a G0/G1 phase block. Apoptosis Analysis
Cell Line: HCT-15 and HCA-7 cells Concentration: 0 µM, 200 µM, 400 µM, 600 µM, 800 µM, 900 µM, and 1000 µM Incubation Time: 72 hours Result: Induced cell apoptosis. Western Blot Analysis
Cell Line: HCT-15 and HCA-7 cells Concentration: 900 µM Incubation Time: 4 hours, 8 hours, 16 hours, 24 hours, 32 hours, 48 hours and 72 hours Result: Decreased levels of Cyclin D1 protein. -
体内研究
(S)-(+)-Ibuprofen (15 mg/kg/day; intraperitoneal injection; five days a week; for 4 weeks) treatment inhibits tumor growth of HCA-7 and HCT-15 xenografts in the nude mice model.
Animal Model: NMRI (nu/nu) male mice (6-8 week old ) injected with HCA-7 and HCT-15 cells Dosage: 15 mg/kg/day Administration: Intraperitoneal injection; five days a week; for 4 weeks Result: Inhibited tumor growth of HCA-7 and HCT-15 xenografts in mice. - 用途 用作解热镇痛药
- 更新日期：2024/11/08
- 产品编号：33320
- 产品名称：(S)-(+)-布洛芬 (S)-(+)-Ibuprofen, 99%, Thermo Scientific Chemicals
- CAS编号：51146-56-6
- 包装：1g
- 价格：514元
- 更新日期：2024/11/08
- 产品编号：33320
- 产品名称：(S)-(+)-布洛芬 (S)-(+)-Ibuprofen, 99%, Thermo Scientific Chemicals
- CAS编号：51146-56-6
- 包装：5g
- 价格：1295元
- 公司名称：Kleos Pharma
- 联系电话：--
- 电子邮件：guedj.gregory@kleos-pharma.com
- 国家：法国
- 产品数：298
- 优势度：58
- 公司名称：Unipex
- 联系电话：--
- 电子邮件：hemical@unipex.com
- 国家：法国
- 产品数：267
- 优势度：58
- 公司名称：Kemprotec Limited (France)
- 联系电话：--
- 电子邮件：
- 国家：法国
- 产品数：74
- 优势度：58
- 公司名称：Portail Substances Chimiques
- 联系电话：--
- 电子邮件：webmestre-substances@ineris.fr
- 国家：法国
- 产品数：6024
- 优势度：58
