没食子酸甲酯
- CAS号:99-24-1
- 英文名:Methyl gallate
- 中文名:没食子酸甲酯
- CBNumber:CB0265566
- 分子式:C8H8O5
- 分子量:184.15
- MOL File:99-24-1.mol
- 熔点 :201-204 °C
- 沸点 :278.08°C (rough estimate)
- 密度 :1.3840 (rough estimate)
- 折射率 :1.5690 (estimate)
- 储存条件 :Inert atmosphere,Room Temperature
- 溶解度 :ethanol: 50 mg/mL, clear
- 酸度系数(pKa) :8.04±0.23(Predicted)
- 形态 :Crystalline Powder
- 颜色 :White to slightly beige
- 水溶解性 :SOLUBLE IN HOT WATER
- Merck :14,4345
- BRN :2113180
- InChIKey :FBSFWRHWHYMIOG-UHFFFAOYSA-N
- LogP :0.860
- CAS 数据库 :99-24-1(CAS DataBase Reference)
- EPA化学物质信息 :Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1)
- 危险品标志 :Xn,Xi
- 危险类别码 :22-36/37/38-43
- 安全说明 :26-36/37-24/25
- WGK Germany :3
- RTECS号 :LW8000000
- TSCA :Yes
- 海关编码 :29182900
没食子酸甲酯 MSDS
Methyl gallate
没食子酸甲酯性质、用途与生产工艺
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试剂用途
没食子酸甲酯通过抑制CD4+CD25+调节性T细胞的浸润表现出强大的抗肿瘤活性。
- 生物活性 Methyl gallate是具有抗氧化,抗癌和抗炎活性的植物酚类。Methyl gallate也可抑制细菌活性。Methyl gallate 还具有抗 HIV-1 和 HIV-1 酶的抑制活性。
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靶点
Bacterial
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体外研究
The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL). Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H 2 O 2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H 2 O 2 (8.0 mM) for a 3 h period. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate.
- 化学性质 单斜棱状结晶(甲醇)。熔点为201-203℃(157℃,水合物或溶剂化的结晶)。溶于热水、乙醇、乙醚。
- 用途 联苯双酯的中间体。也是橡胶防老剂。
- 用途 用作联苯双酚和其他药物的中间体
- 生产方法 用没食子酸与甲醇在硫酸催化下酯化制得。
- 更新日期:2024/11/08
- 产品编号:L05926
- 产品名称:3,4,5-三羟基苯甲酸甲酯, 98% Methyl 3,4,5-trihydroxybenzoate, 98%
- CAS编号:99-24-1
- 包装:50g
- 价格:481元
- 更新日期:2024/11/08
- 产品编号:L05926
- 产品名称:3,4,5-三羟基苯甲酸甲酯, 98% Methyl 3,4,5-trihydroxybenzoate, 98%
- CAS编号:99-24-1
- 包装:250g
- 价格:1476元
- 公司名称:TCI Europe
- 联系电话:320-37350700
- 电子邮件:sales@tcieurope.eu
- 国家:欧洲
- 产品数:23671
- 优势度:75