77-21-4
中文名称
格鲁米特
英文名称
DL-Glutethimide
CAS
77-21-4
EINECS 编号
201-012-0
分子式
C13H15NO2
MDL 编号
MFCD00056091
分子量
217.26
MOL 文件
77-21-4.mol
结构式
基本信息
中文别名
3-乙基-3-苯基-2,6-哌啶二酮
格鲁米特
DEA限制
导眠能
格鲁米特
DEA限制
导眠能
英文别名
2-ethyl-2-phenylglutarimide
3-ETHYL-3-PHENYL-2,6-PIPERIDINEDIONE
D,L-GLUTETHIMIDE
GLUTETHIMIDE
RARECHEM AB PP 2824
(R,S)-3-ethyl-3-phenyl-2,6-piperidinedione
2,6-Piperidinedione, 3-ethyl-3-phenyl-
2,6-piperidinedione,3-ethyl-3-phenyl
2-ethyl-2-phenyl-glutarimid
2-Phenyl-2-ethylglutaric acid imide
2-phenyl-2-ethylglutaricacidimide
3-Ethyl-3-phenyl-2,6-diketopiperidine
3-Ethyl-3-phenyl-2,6-dioxopiperidine
3-Phenyl-3-ethyl-2,6-diketopiperidine
3-Phenyl-3-ethyl-2,6-dioxopiperidine
Alfimid
alpha-Ethyl-alpha-phenylglutarimide
alpha-Phenyl-alpha-ethylglutaric acid imide
alpha-phenyl-alpha-ethylglutaricacidimide
alpha-Phenyl-alpha-ethylglutarimide
3-ETHYL-3-PHENYL-2,6-PIPERIDINEDIONE
D,L-GLUTETHIMIDE
GLUTETHIMIDE
RARECHEM AB PP 2824
(R,S)-3-ethyl-3-phenyl-2,6-piperidinedione
2,6-Piperidinedione, 3-ethyl-3-phenyl-
2,6-piperidinedione,3-ethyl-3-phenyl
2-ethyl-2-phenyl-glutarimid
2-Phenyl-2-ethylglutaric acid imide
2-phenyl-2-ethylglutaricacidimide
3-Ethyl-3-phenyl-2,6-diketopiperidine
3-Ethyl-3-phenyl-2,6-dioxopiperidine
3-Phenyl-3-ethyl-2,6-diketopiperidine
3-Phenyl-3-ethyl-2,6-dioxopiperidine
Alfimid
alpha-Ethyl-alpha-phenylglutarimide
alpha-Phenyl-alpha-ethylglutaric acid imide
alpha-phenyl-alpha-ethylglutaricacidimide
alpha-Phenyl-alpha-ethylglutarimide
所属类别
原料药：其它神经系统用药
物理化学性质
| 熔点 | 84°C |
| 沸点 | 357.82°C (rough estimate) |
| 密度 | 1.0960 (rough estimate) |
| 折射率 | 1.5300 (estimate) |
| 闪点 | 9℃ |
| 储存条件 | -20°C |
| 酸度系数(pKa) | pKa 11.8 (Uncertain) |
| 水溶解性 | 0.95g/L(27 ºC) |
| CAS 数据库 | 77-21-4(CAS DataBase Reference) |
| NIST化学物质信息 | Glutethimide(77-21-4) |
安全数据
| 危险性符号(GHS) |    GHS02,GHS06,GHS08 |
| 警示词 | 危险 |
| 危险性描述 | H225-H301+H311+H331-H370 |
| 防范说明 | P210-P260-P280-P301+P310-P311 |
| 危险品标志 | Xn |
| 危险类别码 | R22 |
| 安全说明 | S36 |
| 危险品运输编号 | 3249 |
| WGK Germany | 1 |
| RTECS号 | MA4725000 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 海关编码 | 29251200 |
| 毒害物质数据 | 77-21-4(Hazardous Substances Data) |
| 毒性 | Glutethimide, and a structurally similar compound methyprylon, has been used occasionally as a sedative-hypnotic, although glutethimide’s use for longer than 3 days is not recommended and it is rarely, if ever, prescribed today. Glutethimide causes a skin rash in nearly 10% of those using it, and although it was once thought to produce less respiratory depression than the barbiturates its overdose fatality record is not good. Much of the drug’s action can be attributed to 4-hydroxyglutethimide, which is more than twice as potent and has a long half-life. Like many other sedativehypnotics, abrupt withdrawal after chronic use or abuse resembles that of ethanol or the barbiturates and must be managed accordingly. |
知名试剂公司产品信息
77-21-4(sigmaaldrich)
Sigma Aldrich