482-45-1
基本信息
白芷甲素
异欧芹属素乙
4-(3-甲基丁-2-烯氧基)呋喃并[3,2-g]苯并吡喃-7-酮
ISOIMPERATORIN
4-(3-Methyl-but-2-enyloxy-furo[3,2-g]chromen-7-one
ISOIMPERATORIN(P)
Isomperatorin
4-(3-Methylbut-2-enoxy)furo[3,2-g]chromen-7-one
4-(3-Methyl-but-2-enyloxy-furo[3,2-γ],chromen-7-one
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-
buten-1-yl)oxy]-
4-(Isopentenyloxy)-7H-furo[3,2-g][1]benzopyran-7-one
4-[(3-Methyl-2-butenyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one
Isoimperatoin
物理化学性质
| 外观性状 | 来源于大风子科罗旦梅 Flacourtiajangomas(Lour.)Raeusch茎,皮 |
| 熔点 | 107-111°C |
| 沸点 | 448.3±45.0 °C(Predicted) |
| 密度 | 1.242±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 可溶于氯仿（少量）、乙酸乙酯（少量 |
| 形态 | neat |
| 颜色 | 白色至淡黄色 |
| BRN | 1291723 |
| LogP | 3.495 (est) |
| CAS 数据库 | 482-45-1(CAS DataBase Reference) |
| NIST化学物质信息 | 7H-furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-butenyl)oxy]-(482-45-1) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H317-H335 |
| 防范说明 | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| 安全说明 | 24/25 |
| WGK Germany | 3 |
| RTECS号 | LV1513000 |
| 海关编码 | 29329990 |
| 毒害物质数据 | 482-45-1(Hazardous Substances Data) |
应用领域
常见问题列表
异欧前胡素具有降压、解痉、抗癌的作用，还可以治疗银屑病。
色谱柱：μbondapak C18柱(150mm×6mm， 5μm);流动相：甲醇-乙腈-0.25mol/L磷酸溶液(9：5：10);流速：1.0ml/min;检测波长：322nm;柱温：室温。
[供试品的制备]
取本品粗粉约50g，用8倍量90%乙醇回流提取3次，每次1.5h，合并提取液，回收乙醇，得浸膏13.70g，并将其与适量经处理过的大孔吸附树脂拌匀，置于经处理过的大孔吸附树脂柱上，依次用水，20%、30%、40%、50%、60%、70%、80%、90%的乙醇冲洗，每次冲至洗脱液无色，水浴蒸干，得膏状物，分别用50%乙醇溶解，定容至50ml。按本法色谱条件进行测定。
| Target | Value |
|
AChE
(Cell-free assay) | 74.6 μM |
During a screening program for new agrochemicals from Chinese medicinal herbs, the ethanol extract of Notopterygium incisum rhizomes is found to possess strong nematicidal activity against the two species of nematodes, Bursaphelenchus xylophilus and Meloidogyne incognita . Based on bioactivity-guided fractionation, the four constituents are isolated from the ethanol extract and identified as Columbianetin, Falcarindiol, Falcarinol, and Isoimperatorin. Isoimperatorin also has LC 50 values of 21.83 μg/mL against B. xylophilus . When using 15 min UV light treatment, falcarindiol, falcarinol, and isoimperatorin demonstrated almost five times more toxic to the southern root-knot nematodes than in dark treatment while columbianetin showed only two times more toxic. isoimperatorin has been demonstrated to possess insecticidal activity against several insects, such as the cabbage aphid ( Brevicoryne brassicae ). Isoimperatorin is identified in the active fraction of Angelica dahurica (AD) extract. Isoimperatorin is usually used as the internal standard (IS).