38953-85-4

基本信息
异黄链霉素
异牡荆黄素, 来源于山楂树
异牡荆素(UNDER DEVELOPMENT)
4H-1-BENZOPYRAN-4-ONE,6-尾-D-GLUCOPYRANOSYL-5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-
SAPONARETIN
SAPOMARETOM
HOMOVITEXIN
Vitexin Isomer
6-C-Glucosylapigenin
APIGENIN-6-C-GLUCOSIDE
Isovitexin (Saponaretin
Apigenin 6-C-β-D-glucoside
ISOVITEXIN
APIGENIN 6-C-Β-D-GLUCOSIDE
物理化学性质
外观性状 | 淡黄色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于山楂叶,竹叶,新西兰牡荆 Vitex lucens,滨牡荆 Virex littoralis,皂荚 Gleditsia sinensis [Syn.Gleditsia horrida],酸角 Tamarindus indica,亚麻 Linum usitatissimum,獐牙菜 Swertia pseudochinensis.。 |
熔点 | 257-258 °C |
沸点 | 807.0±65.0 °C(Predicted) |
密度 | 1.686±0.06 g/cm3(Predicted) |
储存条件 | ?20°C |
溶解度 | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml |
酸度系数(pKa) | 5.93±0.40(Predicted) |
形态 | neat |
颜色 | 黄色 |
BRN | 66651 |
稳定性 | 吸湿性 |
LogP | 1.280 (est) |
安全数据
危险性符号(GHS) | ![]() GHS07 |
警示词 | 警告 |
危险性描述 | H302-H315-H319-H335 |
防范说明 | P261-P305+P351+P338 |
WGK Germany | 3 |
海关编码 | 29329990 |
应用领域
常见问题列表
异牡荆黄素是从亚洲水稻种得到的黄酮类物质,具有抗氧化、抗炎的活性;Isovitexin 作用与 JNK1/2 的抑制剂类似,能够抑制 NF-κB 的活化。
JNK1
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JNK2
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NF-κB
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Isovitexin protects against LPS-induced oxidative damage by suppressing intracellular ROS generation, and also attenuates the effect of H 2 O 2 on cell viability. Isovitexin (0-100 μg/mL) with LPS (2 μg/mL) is not cytotoxic to RAW 264.7 cells, but 200 μg/mL Isovitexin shows significant cytotoxicity. Isovitexin (25, 50 μg/mL) inhibits LPS-induced increases in TNF-α, IL-6, iNOS, and COX-2 levels. Isovitexin (25, 50 μg/mL) also suppresses the IκBα phosphorylation and degradation in RAW 264.7 cells, and such an effect is consistent with that of JNK1/2 inhibitor.
Isovitexin (50 and 100 mg/kg, i.p.) causes less severe histopathological changes in the lung sections, and reduces inflammatory cell count in LPS-induced mice. Isovitexin (50 and 100 mg/kg, i.p.) protects against LPS-induced inflammation and oxidative stress in LPS-induced ALI mice by decreasing TNF-α and IL-6 production, ROS generation, and MPO and MDA content, increasing SOD and GSH levels and effectively inhibiting the protein expression of iNOS and COX-2. Isovitexin (25, 50, 100 mg/kg) dose-dependently reduces the survival rate of LPS/D-gal induced hepatic injury in mice. Isovitexin also inhibits NF-κB activation and up-regulates Nrf2 and HO-1 induced by LPS/D-gal in mice.