440122-66-7
基本信息
7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
WAY200070
WAY 200070
7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
物理化学性质
| 沸点 | 463.6±35.0 °C(Predicted) |
| 密度 | 1.720±0.06 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | 二甲基亚砜：≥20mg/mL |
| 酸度系数(pKa) | 7.26±0.40(Predicted) |
| 形态 | 固体 |
| 颜色 | White to off-white |
| InChI | 1S/C13H8BrNO3/c14-10-5-9(17)6-11-12(10)18-13(15-11)7-1-3-8(16)4-2-7/h1-6,16-17H |
| InChIKey | BAAILVWEAXFTSF-UHFFFAOYSA-N |
| SMILES | Oc1ccc(cc1)-c2nc3cc(O)cc(Br)c3o2 |
安全数据
| 危险性符号(GHS) |  GHS06 |
| 警示词 | 危险 |
| 危险性描述 | H301-H319 |
| 防范说明 | P264-P270-P280-P301+P310-P305+P351+P338-P337+P313 |
| 危险品标志 | T |
| 危险类别码 | 25-36 |
| 安全说明 | 26-45 |
| 危险品运输编号 | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| 危险等级 | 6.1 |
| 存储类别 | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| 危险性类别 | Acute Tox. 3 Oral Eye Irrit. 2 |
制备方法
67-56-1
440123-20-6
![7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇](/CAS/20180808/GIF/440122-66-7.gif)
440122-66-7
步骤e）7-溴-2-(4-羟基苯基)-1,3-苯并恶唑-5-醇的合成路线a）操作如下：在-70℃条件下，将三溴化硼（1M，89.9mL，89.8mmol）逐滴加入到7-溴-5-甲氧基-2-(4-甲氧基苯基)-1,3-苯并恶唑（10.0g，29.94mmol）与二氯甲烷（50mL）的悬浮液中。反应混合物逐渐升温至室温，期间悬浮液转变为黑色溶液。室温下持续搅拌反应混合物2天后，将其缓慢倒入预冷（0℃）的乙醚（1000mL）中。随后，在20分钟内缓慢加入甲醇（200mL）至上述混合物中。将混合液倒入水（1.5L）中，分离有机层，用水洗涤三次，并用无水硫酸镁干燥。通过蒸发浓缩后，从丙酮/乙醚/己烷混合溶剂中结晶，得到灰白色固体产物（8.4g，收率92%，熔点298-299℃）；质谱分析显示m/e 306（M + H）+。
参考文献：
[1] Patent: US2003/199562, 2003, A1
7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-101271 | 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 WAY-200070 | 440122-66-7 | 5mg | 400元 |
| 2026/09/15 | HY-101271 | 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 WAY-200070 | 440122-66-7 | 10mM * 1mLin DMSO | 440元 |
| 2026/09/15 | HY-101271 | 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 WAY-200070 | 440122-66-7 | 10mg | 660元 |
常见问题列表
IC50: 2.3 nM (ERRβ), 155 nM (ERRα)
Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.