348-67-4
基本信息
D-蛋氨酸
D-甲硫氨酸
D-蛋氨酸/D-甲硫氨酸
d-2-amino-4-(methylthio)butyric acid
D-BANTHIONINE
D-LOBAMINE
D-METHIONINE
H-D-MET-OH
(R)-2-AMINO-4-(METHYLMERCAPTO)BUTYRIC ACID
(r)-methionine
d-methionin
D-Metionien
Methionine d-form
Methionine, D-
R-Methionine
D-METHIONINE, 99+% (98% EE/GLC)
D-Methionine,99%
(r)-2-amino-4-(methylthio)butyric acid
D-Methionine (9CI)
Methionine, D- (8CI)
NSC 45689
d-metionien (australian)
物理化学性质
| 外观性状 | D-蛋氨酸为白色结晶。溶于水、稀酸及碱，极微溶于醇，不溶于醚。 |
| 熔点 | 273-275 °C |
| 比旋光度 | -24 º (c=8, 6N HCl) |
| 沸点 | 306.9±37.0 °C(Predicted) |
| 密度 | 1.113 (estimate) |
| 折射率 | 1.5216 (estimate) |
| 储存条件 | 0-6°C |
| 溶解度 | 53g/l（20°C） |
| 酸度系数(pKa) | 2.23±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至灰白色 |
| 水溶解性 | 53 g/L (20 ºC) |
| Merck | 14,5975 |
| BRN | 1722293 |
| 稳定性 | 稳定的。与强氧化剂不相容。 |
| 主要应用 | cell analysis peptide synthesis |
| InChI | 1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m1/s1 |
| InChIKey | FFEARJCKVFRZRR-SCSAIBSYSA-N |
| SMILES | CSCC[C@@H](N)C(O)=O |
| LogP | 0.370 (est) |
| CAS 数据库 | 348-67-4(CAS DataBase Reference) |
| NIST化学物质信息 | D-(l)-Methionine(348-67-4) |
| EPA化学物质信息 | D-Methionine (348-67-4) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H302-H315-H319-H332-H335 |
| 防范说明 | P261-P280-P305+P351+P338 |
| 危险品标志 | Xi |
| 危险类别码 | R33 |
| 安全说明 | S22-S24/25 |
| WGK Germany | 3 |
| RTECS号 | PD0455000 |
| TSCA | Yes |
| 海关编码 | 29309090 |
| 存储类别 | 11 - Combustible Solids |
应用领域
制备方法
1509-92-8
348-67-4
以N-乙酰-D-蛋氨酸为底物测定N-d-AAase活性的一般步骤如下：首先，将N-d-AAase与N-乙酰基-D-蛋氨酸在4℃下孵育。随后，加入含有d-氨基酸氧化酶（与辣根过氧化物酶偶联）、过氧化物酶（10 U/mL）、4-氨基安替比林（0.04 mg/mL）和苯酚（0.8 mM）的比色溶液混合物。在520 nm波长下测量吸光度（OD）。酶活性单位定义为每分钟催化生成1 μmol D-蛋氨酸的量。蛋白质浓度通过Bradford方法测定，以牛血清白蛋白作为标准[32]。动力学参数kcat和Km通过将初始速率作为底物浓度的函数，拟合至Michaelis-Menten方程来确定。
参考文献：
[1] Journal of the American Chemical Society, 1953, vol. 75, p. 4058
[2] Journal of Biological Chemistry, 1952, vol. 194, p. 455,458
[3] Journal of the American Chemical Society, 1951, vol. 73, p. 4604
[4] Bulletin of the Agricultural Chemical Society of Japan, 1957, vol. 21, p. 235,237
[5] Bioscience, biotechnology, and biochemistry, 1992, vol. 56, # 9, p. 1392 - 1395
图谱信息
D-蛋氨酸(348-67-4)质谱(MS)D-蛋氨酸(348-67-4)核磁图(1HNMR)D-蛋氨酸(348-67-4)红外图谱(IR1)D-蛋氨酸(348-67-4)红外图谱(IR2)D-蛋氨酸(348-67-4)Raman光谱知名试剂公司产品信息
D-Methionine, 99+%(348-67-4) Acros Organics
D-Methionine, 99%(348-67-4) Alfa Aesar
D-Methionine,>99.0%(T)(348-67-4) TCI Shanghai
D-蛋氨酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/07/06 | B21213 | D-蛋氨酸, 99% D-Methionine, 99% | 348-67-4 | 5g | 160元 |
| 2026/07/06 | 22721 | D-蛋氨酸 D-Methionine, 99+% | 348-67-4 | 100g | 3068元 |
| 2026/06/06 | M0102 | D-蛋氨酸 D-Methionine | 348-67-4 | 1G | 90元 |
常见问题列表
GABA A receptor
The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. In plasma, an early CP hydrolysis product reacts with Methionine to form a 1:1 complex that is followed by the formation of a 2:1 compound at a later time point. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities.
When Methionine (D-methionine) is administered along with cisplatin the cell density is 0.8±0.070 (SEM), significantly larger than in rats treated with only cisplatin (P<0.01) while not significantly different from controls or from animals treated only with D-methionine (P>0.05). When Methionine is administered alone the average cell density is 0.95±0.099 (SEM) and not significantly different from controls (P>0.05).