225937-10-0
基本信息
DL-儿茶素
(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚
D(+)-儿茶精
D(+)-儿茶素(四水)
D(+)-儿茶酸
反式-3,3ˊ,4ˊ,4,7-五羟基黄烷
四水合-D(+)儿茶素
(+)-儿茶精
(+)-儿茶素(一水物)
(2R,3S)-2-(3,4-二羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7-三醇一水物
(2R,3S)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL
(2R,3S)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL HYDRATE
(+)-3,3',4',5,7-FLAVANPENTOL HYDRATE
(+)-3,3',4',5,7-FLAVANPENTOL MONOHYDRATE
3,3',4',5,7-PENTAHYDROXYFLAVANE HYDRATE
(+)-C
(+)-CATECHIN HYDRATE
(+)-CATECHIN MONOHYDRATE
CATECHOL (FLAVAN), HYDRATE
CATECHUIC ACID (HYDRATE)
(+)-CYANIDOL-3
(+)-CYANIDOL-3, HYDRATE
CYANIDOL HYDRATE
D-CATECHIN
D-(+)-CATECHIN HYDRATE
D-CATECHIN HYDRATE
D-CATECHOL HYDRATE
(+)-TRANS-3,3',4',5,7-PENTAHYDROXYFLAVANE HYDRATE
TRANS-3,3',4',5,7-PENTAHYDROXYFLAVANE HYDRATE
物理化学性质
| 熔点 | 175-177 °C (anhydrous)(lit.) |
| 比旋光度 | 26 º (C=1 IN H2O) |
| 储存条件 | 2-8°C |
| 溶解度 | 乙醇：可溶50mg/mL |
| 形态 | 粉末 |
| 颜色 | 黄色至黄色带棕褐色 |
| 旋光性 (optical activity) | [α]/D +26±2°, c = 1 in H2O |
| Merck | 13,1912 |
| BRN | 3595244 |
| CAS 数据库 | 225937-10-0(CAS DataBase Reference) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319-H335 |
| 防范说明 | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| 危险品标志 | Xi |
| 危险类别码 | R36/37/38 |
| 安全说明 | S26-S36 |
| WGK Germany | 3 |
| F | 8-10-23 |
| 海关编码 | 29329990 |
应用领域
知名试剂公司产品信息
(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | 46302 | (+)-儿茶素水合物 (+)-Catechin hydrate, Thermo Scientific Chemicals | 225937-10-0 | 1g | 876元 |
| 2024/11/08 | 46302 | (+)-儿茶素水合物 (+)-Catechin hydrate, Thermo Scientific Chemicals | 225937-10-0 | 5g | 3395元 |
| 2024/11/08 | C0705 | (+)-儿茶素 水合物 (+)-Catechin Hydrate | 225937-10-0 | 1g | 130元 |
常见问题列表
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COX-1 1.4 μM (IC 50 ) |
(+)-Catechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC 50 of 1.4 μM. A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC 50 of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. The expression levels of Caspase-3 , -8 , and -9 and p53 in MCF-7 cells treated with 150 μg/mL (+)-Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells.
Animals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively).