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186763-78-0

供应商 相关产品 基本信息 常见问题列表 理化性质 应用领域 人参皂苷 RG5价格(试剂级)

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基本信息

英文
Ginsenoside-Rg5
中文
人参皂苷 RG5
英文名称
Ginsenoside-Rg5
Ginsenoside Rg5, >99%
Ginsenoside Rg5, 98%, from Panax ginseng C. A. Mey.
β-D-Glucopyranoside, (3β,12β,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-β-D-glucopyranosyl-
b-D-Glucopyranoside, (3b,12b,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-b-D-glucopyranosyl-
(3beta,12beta,20E)-12-Hydroxydammara-20(22),24-dien-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
(8ξ,9ξ,12α,13ξ,14β,17β)-12-Hydroxy-4,4,7,10,14-pentamethyl-17-[(2 E)-6-methyl-2,5-heptadien-2-yl]gonan-3-yl 2-O-β-D-glucopyranosyl- β-D-glucopyranoside
CAS
186763-78-0
中文名称
人参皂甙 RG5
人参皂苷 RG5
人参皂苷RG5对照品
人参皂苷RG5标准品
人参皂苷RG5, 来源于人参
人参皂甙 RG5?, >99%
分子式
C42H70O12
分子量
767
MOL 文件
186763-78-0.mol

常见问题列表

简介

人参皂苷 RG5提取自蒸参,可用于含量测定/鉴定/药理实验等。


生物活性
Ginsenoside Rg5 是红参的主要成分。Ginsenoside Rg5 阻断 IGF-1 与其受体的结合,IC50 约为90 nM。Ginsenoside Rg5 还通过抑制 NF-κB p65 的 DNA 结合活性来抑制 COX-2 的 mRNA 表达。
靶点

p65

COX-2

IGF-1R

90 nM (IC 50 )


体外研究

Ginsenoside Rg5 plays a novel role as an IGF-1R agonist. Ginsenoside Rg5 binds to IGF-1R with an IC 50 value of ~90 and its angiogenic activity is inhibited by IGF-1R knockdown. To investigate the possible interaction of Ginsenoside Rg5 with IGF-1R, a docking analysis is performed. Docking results show that Ginsenoside Rg5 binds strongly at two sites, A and B, with K d values of 20 and 27 nM, respectively, to the cysteine-rich domain of IGF-1R. Pretreatment with Rg5 blocks the binding of radiolabeled IGF-1 to HUVECs with an IC 50 value of ~90 μM, which is greater than an IC 50 value of ~1.4 nM for unlabeled IGF-1. The results from MTT assay show that MCF-7 cell proliferation is inhibited by Ginsenoside Rg5 treatment for 24, 48 and 72 h in a dose-dependent manner. Ginsenoside Rg5 at different concentrations (0, 25, 50 and 100 μM), induce cell cycle arrest in G0/G1 phase through regulation of cell cycle-related proteins in MCF-7 cells.


体内研究

Ginsenoside Rg5 inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65 in lipopolysaccharides (LPS)-stimulated BV2 microglial cells. Rg5 pretreated group mice show declined expression of NF-κB p65 and COX-2. In the group treated with low dose of Ginsenoside Rg5 (10 mg/kg), there is remarkable tubular damage and infiltration of inflammatory cells. However, at the higher dose of Ginsenoside Rg5 (20 mg/kg), tubules markedly appeare histologically normal and no inflammation and cast formation is observed in kidney tissues.


理化性质

外观性状
白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于人参。
沸点 
855.6±65.0 °C(Predicted)
密度 
1.28±0.1 g/cm3 (20 ºC 760 Torr)
储存条件 
2-8°C
酸度系数(pKa)
12.85±0.70(Predicted)

应用领域

用途1
用于含量测定/鉴定/药理实验等
用途2
人参皂苷Rg5是蒸参中提取的主要成分,具有抗炎症作用。

人参皂苷 RG5价格(试剂级)

人参皂苷 RG5价格(试剂级)
更新日期产品编号产品名称CAS号包装价格
2023/01/06HY-N0908人参皂苷 RG5
Ginsenoside Rg5
186763-78-05mg2800元
2023/01/06HY-N0908人参皂苷 RG5
Ginsenoside Rg5
186763-78-010mM * 1mLin DMSO3797元
2023/01/06HY-N0908人参皂苷 RG5
Ginsenoside Rg5
186763-78-010mg4500元

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