General Description
Bright yellow powder.
Reactivity Profile
5-NITRO-O-TOLUIDINE(99-55-8) is incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides and chloroformates.
Air & Water Reactions
Insoluble in water. This compound is sensitive to moisture, light, or prolonged exposure to air.
Fire Hazard
Flash point data for this chemical are not available; however, 5-NITRO-O-TOLUIDINE is probably combustible.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical
attention. Give large quantities of water and induce vomiting.
Do not make an unconscious person vomit.
Shipping
UN2660 Nitrotoluidines (mono), Hazard Class:
6.1; Labels: 6.1-Poisonous materials.
Incompatibilities
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides;
chloroformates.
Description
2-Methyl-5-nitroaniline, also known as 5-nitro-o-toluidine, is an intermediate compound in the synthesis of a wide range of azo dyes and is an in vivo metabolic product of 2,4-dinitrotoluene.
Chemical Properties
5-Nitro-o-toluidine is a yellow, crystalline
solid.
Chemical Properties
yellow powder
Waste Disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
Uses
5-Nitro-o-toluidine is used in the synthesis of numerous dyes.
Definition
ChEBI: A C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine.
Preparation
2-Methyl-5-nitrobenzenamine?in concentrated sulfuric acid nitration.
Toxicology
Genetic toxicity studies for 2-methyl-5-nitroaniline indicate generally positive results in
reverse-mutation assays in Salmonella typhimurium and Escherichia coli, and in Syrian hamster
embryo (SHE) cell transformation assays; the compound is weaker in potency than other 2,4-dinitrotoluene
metabolites.
Carcinogenicity
There
are no data available for evaluating carcinogenic risk to
humans. When 5-nitro-o-toluidine was administered in a
dietary feeding study to F344 rats (50 or 100 ppm) and
B6C3F1 mice (1200 or 2300 ppm) of both sexes, hepatocellular
carcinomas were produced in mice but not in rats.
Purification Methods
Acetylate the aniline, and the acetyl derivative is crystallised to constant melting point; then hydrolyse it with 70% H2SO4 and the free base is regenerated by treatment with NH3 [Bevan et al. J Chem Soc 4284 1956]. [Beilstein 12 H 844. 12 IV 1807.]
