Supplier Related Products Identification Chemical Properties Safety Data Raw materials And Preparation Products Questions and Answers (Q&A) Well-known Reagent Company Product Information
WebSite >  CAS DataBase List  > 98079-52-8

98079-52-8

Supplier Related Products Identification Chemical Properties Safety Data Raw materials And Preparation Products Questions and Answers (Q&A) Well-known Reagent Company Product Information

Product Image

Identification

Name
Lomefloxacin hydrochloride
CAS
98079-52-8
Synonyms
1-ETHYL-6,8-DIFLUORO-1,4-DIHYDRO-7-[3-METHYL-1-PIPERAZINYL]-4-OXO-3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE
LOMEFLOXACIN HCL
LOMEFLOXACIN HYDROCHLORIDE
1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylicacimonohydrochloride
bareon
ny198
sc-47111
Lomoefloxacin HCL
LomefloxacineHCl
Chimono
Lomebact
Maxaquin
Okacin
Okacyn
3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride (9CI)
Mazaquin
Uniquin
1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acimonohydrochloride
bareonny
1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride
Molecular Formula
C17H20ClF2N3O3
MDL Number
MFCD00214312
Molecular Weight
387.81
MOL File
98079-52-8.mol

Chemical Properties

Appearance
White powder with no smell, bitter taste
mp 
290-3000C
storage temp. 
−20°C

Usage
Fluorinated quinolone antibacterial. DNA gyrase antagonist
Merck 
5562
CAS DataBase Reference
98079-52-8(CAS DataBase Reference)

Safety Data

Hazard Codes 
Xn
Risk Statements 
R22:Harmful if swallowed.
WGK Germany 
3

RTECS 
VB1997500

HS Code 
29339900

Raw materials And Preparation Products

Questions and Answers (Q&A)

Description
Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.
References
Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.

Well-known Reagent Company Product Information

SupplierMore